PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane

Stable Identifier
R-HSA-8849969
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, early endosome membrane
ReviewStatus
5/5
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PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane
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Characterization of human INPP5F (SAC2) identified that it is a 4-phosphatase with highest activity against PI(4,5)P2, PI(3,4)P2, and PI(3,4,5)P3, generating PI(5)P, PI(3)P and PI(3,5)P2 respectively (Nakatsu et al. 2015, Hsu et al. 2015). Inpp5f -/- mice have elevated level of PIP3 and exhibit accentuated cardiac hypertrophy as measured by heart size, myocyte size and gene expression (Zhu et al. 2009).
Literature References
PubMed ID Title Journal Year
25869668 Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway

Messa, M, Zou, Y, Strittmatter, SM, Nández, R, De Camilli, P, Nakatsu, F, Czapla, H

J. Cell Biol. 2015
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphatidylinositol phosphate 4-phosphatase activity of INPP5F [early endosome membrane]

Physical Entity
INPP5F [early endosome membrane] (Homo sapiens)
Activity
phosphatidylinositol phosphate 4-phosphatase activity (GO:0034596)
Orthologous Events
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Bos taurus)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Caenorhabditis elegans)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Canis familiaris)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Danio rerio)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Dictyostelium discoideum)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Drosophila melanogaster)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Gallus gallus)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Mus musculus)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Plasmodium falciparum)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Rattus norvegicus)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Sus scrofa)
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane (Xenopus tropicalis)
Authored
Jupe, S  (2015-12-18)
Reviewed
D'Eustachio, P  (2016-01-05)
Created
Jupe, S  (2015-12-18)
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