Characterization of human INPP5F (SAC2) identified that it is a 4-phosphatase with highest activity against PI(4,5)P2, PI(3,4)P2, and PI(3,4,5)P3, generating PI(5)P, PI(3)P and PI(3,5)P2 respectively (Nakatsu et al. 2015, Hsu et al. 2015). Inpp5f -/- mice have elevated level of PIP3 and exhibit accentuated cardiac hypertrophy as measured by heart size, myocyte size and gene expression (Zhu et al. 2009).