PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane

Stable Identifier
R-HSA-8849969
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Characterization of human INPP5F (SAC2) identified that it is a 4-phosphatase with highest activity against PI(4,5)P2, PI(3,4)P2, and PI(3,4,5)P3, generating PI(5)P, PI(3)P and PI(3,5)P2 respectively (Nakatsu et al. 2015, Hsu et al. 2015). Inpp5f -/- mice have elevated level of PIP3 and exhibit accentuated cardiac hypertrophy as measured by heart size, myocyte size and gene expression (Zhu et al. 2009).

Literature References
PubMed ID Title Journal Year
25869668 Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway

Nakatsu, F, Messa, M, Nández, R, Czapla, H, Zou, Y, Strittmatter, SM, De Camilli, P

J. Cell Biol. 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol phosphate 4-phosphatase activity of INPP5F [early endosome membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created