RAB3GAP1:RAB3GAP2 recruits RAB18:GCDP to ER

Stable Identifier
R-HSA-8850040
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RAB18 is a highly conserved RAB GTPase with roles in Golgi to ER trafficking, lipid droplet formation and the regulation of secretory granules and peroxisomes (Dejgaard et al, 2008; Gerondopoulos et al, 2014; Martin et al, 2005; Ozeki et al, 2005; Vazquez-Martinez et al, 2007; Gronemeyer et al, 2013). RAB18 is recruited to the ER membrane by the RAB18 GEF complex RAB3GAP1:RAB3GAP2, a complex that was initially identified and characterized for its GAP activity towards RAB3 (Gerondopoulos et al, 2013; Fukui et al, 1997; Nagano et al, 1998).

Literature References
PubMed ID Title Journal Year
24891604 Rab18 and a Rab18 GEF complex are required for normal ER structure

Gerondopoulos, A, Bastos, RN, Yoshimura, S, Anderson, R, Carpanini, S, Aligianis, I, Handley, MT, Barr, FA

J. Cell Biol. 2014
15914536 Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane

Ozeki, S, Cheng, J, Tauchi-Sato, K, Hatano, N, Taniguchi, H, Fujimoto, T

J. Cell. Sci. 2005
18664496 Rab18 and Rab43 have key roles in ER-Golgi trafficking

Dejgaard, SY, Murshid, A, Erman, A, Kizilay, O, Verbich, D, Lodge, R, Dejgaard, K, Ly-Hartig, TB, Pepperkok, R, Simpson, JC, Presley, JF

J. Cell. Sci. 2008
16207721 Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism

Martin, S, Driessen, K, Nixon, SJ, Zerial, M, Parton, RG

J. Biol. Chem. 2005
23333653 Localization of Rab proteins to peroxisomes: a proteomics and immunofluorescence study

Gronemeyer, T, Wiese, S, Grinhagens, S, Schollenberger, L, Satyagraha, A, Huber, LA, Meyer, HE, Warscheid, B, Just, WW

FEBS Lett. 2013
17488286 Rab18 inhibits secretory activity in neuroendocrine cells by interacting with secretory granules

Vazquez-Martinez, R, Cruz-Garcia, D, Duran-Prado, M, Peinado, JR, CastaƱo, JP, Malagon, MM

Traffic 2007
9733780 Molecular cloning and characterization of the noncatalytic subunit of the Rab3 subfamily-specific GTPase-activating protein

Nagano, F, Sasaki, T, Fukui, K, Asakura, T, Imazumi, K, Takai, Y

J. Biol. Chem. 1998
9030515 Isolation and characterization of a GTPase activating protein specific for the Rab3 subfamily of small G proteins

Fukui, K, Sasaki, T, Imazumi, K, Matsuura, Y, Nakanishi, H, Takai, Y

J. Biol. Chem. 1997
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