Reactome: A Curated Pathway Database

RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18

Stable Identifier
R-HSA-8850041
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The RAB3GAP1:RAB3GAP2 complex promotes nucleotide exchange of RAB18 at the ER membrane, activating it (Gerondopoulos et al, 2014). How active RAB18 contributes to COPI-independent retrograde Golgi-to-ER traffic remains to be worked out, however a role in tubule tethering is postulated based on the interaction of RAB18 with components of the ER localized NRZ tethering factor (Dejgaard et al, 2008; Gerondopoulos et al, 2014; Gillingham et al, 2014).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
guanyl-nucleotide exchange factor activity of RAB3GAP1:RAB3GAP2:RAB18:GDP [endoplasmic reticulum membrane] RAB3GAP1:RAB3GAP2:RAB18:GDP [endoplasmic reticulum membrane] guanyl-nucleotide exchange factor activity (0005085)
Orthologous Events