RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18

Stable Identifier
R-HSA-8850041
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The RAB3GAP1:RAB3GAP2 complex promotes nucleotide exchange of RAB18 at the ER membrane, activating it (Gerondopoulos et al, 2014). How active RAB18 contributes to COPI-independent retrograde Golgi-to-ER traffic remains to be worked out, however a role in tubule tethering is postulated based on the interaction of RAB18 with components of the ER localized NRZ tethering factor (Dejgaard et al, 2008; Gerondopoulos et al, 2014; Gillingham et al, 2014).

Literature References
PubMed ID Title Journal Year
24891604 Rab18 and a Rab18 GEF complex are required for normal ER structure

Gerondopoulos, A, Bastos, RN, Yoshimura, S, Anderson, R, Carpanini, S, Aligianis, I, Handley, MT, Barr, FA

J. Cell Biol. 2014
18664496 Rab18 and Rab43 have key roles in ER-Golgi trafficking

Dejgaard, SY, Murshid, A, Erman, A, Kizilay, O, Verbich, D, Lodge, R, Dejgaard, K, Ly-Hartig, TB, Pepperkok, R, Simpson, JC, Presley, JF

J. Cell. Sci. 2008
25453831 Toward a comprehensive map of the effectors of rab GTPases

Gillingham, AK, Sinka, R, Torres, IL, Lilley, KS, Munro, S

Dev. Cell 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of RAB3GAP1:RAB3GAP2:RAB18:GDP [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed