SPINK6 binds KLK5

Stable Identifier
R-HSA-8850794
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Extracellular SPINK6 (Serine protease inhibitor Kazal-type 6) binds KLK5 (kallekrein-related peptidase 5), inactivating the latter. KLK5 activity contributes to the process of desquamation, and SPINK6 binding may play a role in the regulation of that process (Meyer-Hoffert et al. 2010).

Literature References
PubMed ID Title Journal Year
20667819 Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases

Meyer-Hoffert, U, Wu, Z, Kantyka, T, Fischer, J, Latendorf, T, Hansmann, B, Bartels, J, He, Y, Gläser, R, Schröder, JM

J. Biol. Chem. 2010
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