SPINK9 binds KLK5

Stable Identifier
R-HSA-8850818
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Extracellular SPINK9 (Serine protease inhibitor Kazal-type 6) binds KLK5 (kallekrein-related peptidase 5), inactivating the latter. KLK5 activity contributes to the process of desquamation, and SPINK9 binding may play a role in the regulation of that process (Brattsand et al. 2009; Meyer-Hoffert et al. 2009).

Literature References
PubMed ID Title Journal Year
19194479 SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor

Brattsand, M, Stefansson, K, Hubiche, T, Nilsson, SK, Egelrud, T

J. Invest. Dermatol. 2009
19190773 Identification of lympho-epithelial Kazal-type inhibitor 2 in human skin as a kallikrein-related peptidase 5-specific protease inhibitor

Meyer-Hoffert, U, Wu, Z, Schröder, JM

PLoS ONE 2009
Participants
Participant Of
Orthologous Events
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