SPINK9 binds KLK5

Stable Identifier
R-HSA-8850818
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Extracellular SPINK9 (Serine protease inhibitor Kazal-type 6) binds KLK5 (kallekrein-related peptidase 5), inactivating the latter. KLK5 activity contributes to the process of desquamation, and SPINK9 binding may play a role in the regulation of that process (Brattsand et al. 2009; Meyer-Hoffert et al. 2009).
Literature References
PubMed ID Title Journal Year
19190773 Identification of lympho-epithelial Kazal-type inhibitor 2 in human skin as a kallikrein-related peptidase 5-specific protease inhibitor

Schröder, JM, Meyer-Hoffert, U, Wu, Z

PLoS ONE 2009
19194479 SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor

Nilsson, SK, Hubiche, T, Brattsand, M, Egelrud, T, Stefansson, K

J. Invest. Dermatol. 2009
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