Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
MYLIP [cytosol]
Stable Identifier
R-HSA-8850908
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase MYLIP ecNumber6.3.2.-/ecNumber, MYLIP_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MYLIP [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MYLIP [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MYLIP [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MYLIP [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MYLIP [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MYLIP [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MYLIP [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MYLIP [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MYLIP [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MYLIP [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
NR1H2 and NR1H3-mediated signaling (Homo sapiens)
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake (Homo sapiens)
Expression of MYLIP regulated by NR1H2,3 (Homo sapiens)
MYLIP [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein clearance (Homo sapiens)
VLDLR internalisation and degradation (Homo sapiens)
MYLIP dimer ubiquitinates VLDLR on Lys-839 (Homo sapiens)
MYLIP dimer [cytosol] (Homo sapiens)
MYLIP [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WY64 MYLIP
Gene Names
MYLIP, BZF1, IDOL, BM-023, PP5242
Chain
chain:1-445
Reference Genes
BioGPS Gene:29116 MYLIP
COSMIC (genes):MYLIP MYLIP
CTD Gene:29116 MYLIP
dbSNP Gene:29116 MYLIP
ENSEMBL:ENSG00000007944 MYLIP
HGNC:21155 MYLIP
KEGG Gene (Homo sapiens):29116 MYLIP
Monarch:29116 MYLIP
NCBI Gene:29116 MYLIP
OMIM:610082 MYLIP
UCSC:Q8WY64 MYLIP
Reference Transcript
RefSeq:NM_013262.3 MYLIP
Other Identifiers
11718006_a_at
11718007_a_at
11757972_s_at
17005077
220319_s_at
223129_x_at
223130_s_at
228098_s_at
2896485
2896486
2896488
2896497
2896498
2896499
2896500
2896501
2896503
2896507
2896508
2896512
2896513
2896514
2896515
2896516
29116
49005_at
8117020
A_14_P108430
A_14_P116038
A_14_P202465
A_23_P31041
A_24_P917123
A_33_P3255914
GE62520
GO:0000209
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0006464
GO:0006511
GO:0007399
GO:0008092
GO:0008150
GO:0009056
GO:0010977
GO:0010989
GO:0016020
GO:0016567
GO:0016740
GO:0030154
GO:0031648
GO:0032802
GO:0032803
GO:0042592
GO:0042632
GO:0043167
GO:0043226
GO:0045732
GO:0046872
GO:0048856
GO:0061630
Hs.20072.1.S1_3p_a_at
ILMN_1656111
PH_hs_0025924
TC06000108.hg
g9437508_3p_a_at
Participant Of
output
Expression of MYLIP regulated by NR1H2,3
hasComponent
MYLIP dimer [cytosol]
hasMember
E3 ligases in proteasomal degradation [cytosol]
Inferred To
Mylip [cytosol] (Mus musculus)
Mylip [cytosol] (Rattus norvegicus)
HPF1 [cytosol] (Saccharomyces cerevisiae)
CSS1 [cytosol] (Saccharomyces cerevisiae)
Homologues of MYLIP [cytosol] (Saccharomyces cerevisiae)
mylipa [cytosol] (Danio rerio)
MYLIP [cytosol] (Bos taurus)
MYLIP [cytosol] (Canis familiaris)
MYLIP [cytosol] (Gallus gallus)
MYLIP [cytosol] (Sus scrofa)
mylip [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_037394.2
OpenTargets
ENSG00000007944
GeneCards
Q8WY64
HPA
ENSG00000007944-MYLIP
Ensembl
ENST00000356840
,
ENSP00000349298
,
ENSG00000007944
PRO
Q8WY64
Orphanet
23128
HMDB Protein
HMDBP09279
PDB
2YHN
,
2YHO
,
6QLZ
,
6QLY
Interactors (39)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q86WV8 Q86WV8
0.718
6
UniProt:Q8N448 LNX2
0.668
4
UniProt:Q8WWW0 RASF5
0.666
4
UniProt:Q9C086 INO80B
1
INO80B [nucleoplasm]
(R-HSA-5689599)
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [cytosol]
(R-HSA-5654207)
SPRED1 [plasma membrane]
(R-HSA-5658225)
0.556
3
UniProt:Q05516 ZBTB16
1
ZBTB16 [cytosol]
(R-HSA-976047)
0.556
3
UniProt:Q99592 ZBT18
0.556
3
UniProt:Q9Y3Q8 T22D4
0.556
3
UniProt:Q96D03 DDT4L
0.556
3
UniProt:Q8TD10 MIPO1
0.556
3
UniProt:D3DTS7 D3DTS7
0.556
3
UniProt:Q9UMF0 ICAM5
1
ICAM5 [plasma membrane]
(R-HSA-197684)
0.556
3
UniProt:P0CG21 NHLC4
0.556
3
UniProt:Q8N8B7-2 TCEANC
0.556
3
UniProt:Q96IK5 GMCL1
0.556
3
UniProt:Q03989 ARI5A
0.556
3
UniProt:Q9NTX9 F217B
0.556
3
UniProt:Q5T7N3 KANK4
0.556
3
UniProt:Q86UR1-2 NOXA1
0.556
5
UniProt:Q5JST6 EFHC2
0.556
3
UniProt:G5E9A7 G5E9A7
0.556
3
UniProt:Q9NQT4 EXOSC5
2
EXOSC5 [nucleoplasm]
(R-HSA-6791550)
EXOSC5 [cytosol]
(R-HSA-429889)
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:P54252 ATXN3
2
ATXN3 [cytosol]
(R-HSA-5625607)
ATXN3 [nucleoplasm]
(R-HSA-6783285)
0.556
3
UniProt:Q92870-2 Q928702
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:Q7Z4V0 ZN438
0.556
3
UniProt:Q6NSM0 Q6NSM0
0.556
6
UniProt:Q9BWG6 SCNM1
0.556
3
UniProt:O43464 HTRA2
0.556
3
UniProt:P55771 PAX9
0.556
6
UniProt:O14901 KLF11
0.556
3
UniProt:Q8TAU3 ZNF417
1
ZNF417 [nucleoplasm]
(R-HSA-1247539)
0.556
3
UniProt:B2RXF5 ZBT42
0.556
3
UniProt:Q96ED9-2 HOOK2
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q9Y2B0 CNPY2
0.508
3
UniProt:P46108-2 CRK
0.488
2
UniProt:Q9UN19 DAPP1
2
DAPP1 [cytosol]
(R-HSA-197950)
p-Y139-DAPP1 [plasma membrane]
(R-HSA-1112650)
0.488
2
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text