NTPDase4 hydrolyzes nucleoside diphosphates

Stable Identifier
R-HSA-8851225
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NTPDase4 (UDPase), encoded by the ENTPD4 gene, belongs to the E-NTPDase family of nucleotide phosphatases. NTPDase4 localizes to the Golgi membrane, with active site on the Golgi lumen side. In the presence of Ca2+, NTPDase4 hydrolyzes nucleoside diphosphates UDP, GDP, CDP and dTDP to nucleoside monophosphates UMP, GMP, CMP and dTMP, respectively (Wang and Guidotti 1998).

Literature References
PubMed ID Title Journal Year
9556635 Golgi localization and functional expression of human uridine diphosphatase J. Biol. Chem. 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
nucleoside-diphosphatase activity of NTPDase4:Ca2+ [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed