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GPR143 [plasma membrane]
Stable Identifier
R-HSA-8851292
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
G-protein coupled receptor 143, GP143_HUMAN, OA1, Ocular albinism type 1 protein
Locations in the PathwayBrowser for interactor UniProt:P11344
Expand all
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
MITF-M-dependent gene expression (Homo sapiens)
Regulation of MITF-M-dependent genes involved in pigmentation (Homo sapiens)
MITF-M-dependent GPR143 expression (Homo sapiens)
GPR143 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
GPR143 binds L-Dopa (Homo sapiens)
GPR143 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51810 GPR143
Gene Names
GPR143, OA1
Chain
chain:1-404
Reference Genes
BioGPS Gene:4935 GPR143
COSMIC (genes):GPR143 GPR143
CTD Gene:4935 GPR143
dbSNP Gene:4935 GPR143
ENSEMBL:ENSG00000101850 GPR143
HGNC:20145 GPR143
KEGG:hsa:4935 GPR143
Monarch:4935 GPR143
NCBI Gene:4935 GPR143
OMIM:300808 GPR143
UCSC:P51810 GPR143
Reference Transcript
RefSeq:NM_000273.2 GPR143
Other Identifiers
11726811_at
17109020
206696_PM_at
206696_at
36778_at
3999161
3999162
3999163
3999164
3999165
3999169
3999170
3999171
3999172
3999173
3999177
3999178
3999179
3999186
3999187
3999188
3999190
3999191
3999200
4935
8171284
A_23_P45560
GE60417
GO:0004930
GO:0005515
GO:0005737
GO:0005764
GO:0005765
GO:0005773
GO:0005794
GO:0005886
GO:0006726
GO:0007165
GO:0007186
GO:0007200
GO:0007218
GO:0007601
GO:0016020
GO:0016324
GO:0031410
GO:0032400
GO:0032402
GO:0032438
GO:0033162
GO:0035240
GO:0035643
GO:0042470
GO:0043226
GO:0050848
GO:0050877
GO:0060089
GO:0072544
GO:0072545
GO:1902908
GO:1903056
HMNXSV003002978
HMNXSV003012253
ILMN_1756261
PH_hs_0004240
PH_hs_0035450
TC0X000851.hg
Z48804_at
g4557806_3p_at
Participates
as an output of
MITF-M-dependent GPR143 expression (Homo sapiens)
as an input of
GPR143 binds L-Dopa (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
as a component of
GPR143:L-Dopa [plasma membrane] (Homo sapiens)
Inferred To
Homologues of GPR143 [plasma membrane]
(Sus scrofa)
GPR143 [plasma membrane]
(Bos taurus)
GPR143 [plasma membrane]
(Canis familiaris)
GPR143 [plasma membrane]
(Gallus gallus)
GPR143 [plasma membrane]
(Sus scrofa)
gpr143 [plasma membrane]
(Xenopus tropicalis)
Gpr143 [plasma membrane]
(Mus musculus)
Gpr143 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_000264.2
Guide to Pharmacology - Targets
203
ENSEMBL
ENST00000467482
,
ENSP00000417161
OpenTargets
ENSG00000101850
HPA
ENSG00000101850-GPR143
PRO
P51810
Pharos - Targets
P51810
GlyGen
P51810
Orphanet
GPR143
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14679 TYR
1
TYR [melanosome membrane]
(R-HSA-5617243)
0.518
4
UniProt:P11344
1
TYR [melanosome membrane]
(R-MMU-5617243)
0.463
2
UniProt:Q16655 MLANA
1
MLANA [melanosome membrane]
(R-HSA-9825829)
0.463
2
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