Reactome | CFHR5 [extracellular region]

CFHR5 [extracellular region]

Stable Identifier

R-HSA-8851419

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Complement factor H-related protein 5, FHR5_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Complement cascade (Homo sapiens)
    - Regulation of Complement cascade (Homo sapiens)
      - CFHR dimers bind C3b (Homo sapiens)
        
        CFHR dimers [extracellular region] (Homo sapiens)
        
        CFHR5 dimer [extracellular region] (Homo sapiens)
        
        CFHR5 [extracellular region] (Homo sapiens)
        
        Cell surface:C3b:CFHR dimers [plasma membrane] (Homo sapiens)
        
        CFHR dimers [extracellular region] (Homo sapiens)
        
        CFHR5 dimer [extracellular region] (Homo sapiens)
        
        CFHR5 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BXR6 CFHR5

Gene Names

CFHR5, CFHL5, FHR5

Chain

signal peptide:1-18, chain:19-569

Reference Genes

BioGPS Gene:81494 CFHR5

COSMIC (genes):CFHR5 CFHR5

CTD Gene:81494 CFHR5

dbSNP Gene:81494 CFHR5

ENSEMBL:ENSG00000134389 CFHR5

HGNC:24668 CFHR5

KEGG:hsa:81494 CFHR5

Monarch:81494 CFHR5

NCBI Gene:81494 CFHR5

OMIM:608593 CFHR5

UCSC:Q9BXR6 CFHR5

Reference Transcript

RefSeq:NM_030787.3 CFHR5

Other Identifiers

11740249_at

16675481

208088_PM_s_at

208088_s_at

2373500

2373512

2373513

2373514

2373515

2373517

2373518

2373519

2373520

2373522

2373523

2373524

2373525

2373526

2373527

7908499

81494

A_14_P125089

A_23_P23759

A_24_P111406

GE83175

GO:0001851

GO:0002376

GO:0005515

GO:0005576

GO:0005615

GO:0006956

GO:0006957

GO:0032091

GO:0032991

GO:0042802

GO:0046982

GO:0051838

GO:0098542

HMNXSV003050832

ILMN_1718248

PH_hs_0014544

TC01001634.hg

g13540562_3p_s_at

Participates

as a component of

CFHR5 dimer [extracellular region] (Homo sapiens)

Inferred To

CFHR5 [extracellular region] (Bos taurus)

CFHR5 [extracellular region] (Canis familiaris)

CFHR5 [extracellular region] (Gallus gallus)

cfh [extracellular region] (Danio rerio)

Homologues of CFHR5 [extracellular region] (Danio rerio)

Homologues of CFHR5 [extracellular region] (Xenopus tropicalis)

svep1l [extracellular region] (Xenopus tropicalis)

f13b [extracellular region] (Xenopus tropicalis)

cfhl2 [extracellular region] (Danio rerio)

cfhl1 [extracellular region] (Danio rerio)

Cross References

RefSeq

NP_110414.1

ENSEMBL

ENST00000256785, ENST00000709541, ENSP00000517752, ENSP00000256785

OpenTargets

ENSG00000134389

HPA

ENSG00000134389-CFHR5

PRO

Q9BXR6

Pharos - Targets

Q9BXR6

Orphanet

CFHR5

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.718	6
UniProt:Q05940 SLC18A2	2	SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372544) SLC18A2 [plasma membrane] (R-HSA-374907)	0.556	3
UniProt:O00559 EBAG9	1	EBAG9 [Golgi membrane] (R-HSA-9018507)	0.556	3
UniProt:O15552 FFAR2	1	FFAR2 [plasma membrane] (R-HSA-443944)	0.556	3
UniProt:Q14973 SLC10A1	1	SLC10A1 [plasma membrane] (R-HSA-194116)	0.556	3
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3

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