NTPDase7 hydrolyzes nucleoside triphosphates

Stable Identifier
R-HSA-8851494
Type
Reaction [transition]
Species
Homo sapiens
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NTPDase7 (LALP1), encoded by the ENTPD7 gene, is a cytoplasmic vesicle membrane-bound nucleotide phosphatase that hydrolyzes nucleoside triphosphates CTP, GTP and UTP to nucleoside diphosphates CDP, GDP and UDP, respectively. NTPDase7 may have a low activity towards ATP and nucleoside diphosphates (Shi et al. 2001). NTPDase7 requires Ca2+ for catalytic activity (Shi et al. 2001). In mice, NTPDase7 was shown to regulate development of IL17-secreting Th17 cells in the small intestine, possibly by regulating extracellular ATP levels (Kusu et al. 2013).

Literature References
PubMed ID Title Journal Year
23241884 Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine

Kusu, T, Kayama, H, Kinoshita, M, Jeon, SG, Ueda, Y, Goto, Y, Okumura, R, Saiga, H, Kurakawa, T, Ikeda, K, Maeda, Y, Nishimura, J, Arima, Y, Atarashi, K, Honda, K, Murakami, M, Kunisawa, J, Kiyono, H, Okumura, M, Yamamoto, M, Takeda, K

J. Immunol. 2013
11278936 Molecular cloning and characterization of a novel mammalian endo-apyrase (LALP1)

Shi, JD, Kukar, T, Wang, CY, Li, QZ, Cruz, PE, Davoodi-Semiromi, A, Yang, P, Gu, Y, Lian, W, Wu, DH, She, JX

J. Biol. Chem. 2001
Participants
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Catalyst Activity
Catalyst Activity
Title
nucleoside-triphosphatase activity of NTPDase7:Ca2+ [endocytic vesicle membrane]
Physical Entity
Activity
Orthologous Events
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Created