GALNT3 transfers GalNAc to FGF23

Stable Identifier
R-HSA-8851619
Type
Reaction [transition]
Species
Homo sapiens
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Fibroblast growth factor 23 (FGF23, aka phosphatonin) is a regulator of phosphate homeostasis and vitamin D metabolism. Its effects are thought to be mediated via the FGFR3c receptor. Glycosylation is necessary for FGF23 secretion from the cell and that is mediated by polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3), which transfers an N-acetylgalactosaminyl (GalNAc) moiety from a high energy donor to threonine 178 on FGF23 (Kato et al. 2006). Competition between proprotein convertase cleavage and O-glycosylation determines the level of secreted active FGF23.

Literature References
PubMed ID Title Journal Year
16638743 Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation

Kato, K, Jeanneau, C, Tarp, MA, Benet-Pages, A, Lorenz-Depiereux, B, Bennett, EP, Mandel, U, Strom, TM, Clausen, H

J. Biol. Chem. 2006
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Catalyst Activity
Title
polypeptide N-acetylgalactosaminyltransferase activity of GALNT3 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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Created