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MEX3C [cytosol]
Stable Identifier
R-HSA-8851640
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
RNA-binding E3 ubiquitin-protein ligase MEX3C ecNumber6.3.2.-/ecNumber, MEX3C_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MEX3C [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MEX3C [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MEX3C [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MEX3C [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MEX3C [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MEX3C [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MEX3C [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MEX3C [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MEX3C [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MEX3C [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5U5Q3 MEX3C
Gene Names
MEX3C, RKHD2, RNF194, BM-013
Chain
chain:1-659
Reference Genes
BioGPS Gene:51320 MEX3C
COSMIC (genes):MEX3C MEX3C
CTD Gene:51320 MEX3C
dbSNP Gene:51320 MEX3C
ENSEMBL:ENSG00000176624 MEX3C
ENSEMBL_homo_sapiens_GENE:ENSG00000176624.12 MEX3C
HGNC:28040 MEX3C
KEGG Gene (Homo sapiens):51320 MEX3C
Monarch:51320 MEX3C
NCBI Gene:51320 MEX3C
OMIM:611005 MEX3C
UCSC:Q5U5Q3 MEX3C
Reference Transcript
RefSeq:NM_016626.4 MEX3C
Other Identifiers
11720424_a_at
11758191_s_at
16855318
218247_PM_s_at
218247_s_at
222567_PM_s_at
222567_s_at
3808097
3808098
3808099
3808100
3808109
3808110
3808111
51320
54069_at
8023377
91416_at
A_23_P50137
A_24_P416543
GE54967
GO:0003415
GO:0003676
GO:0003723
GO:0003824
GO:0005515
GO:0005634
GO:0005737
GO:0016740
GO:0030154
GO:0043226
GO:0045598
GO:0046872
GO:0048856
GO:0061630
GO:0097009
GO:0140096
HMNXSV003011402
Hs.12830.0.S1_3p_a_at
ILMN_1658182
PH_hs_0001223
TC18000517.hg
g7706165_3p_a_at
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
mex3c [cytosol]
(Xenopus tropicalis)
MEX3C [cytosol]
(Bos taurus)
MEX3C [cytosol]
(Canis familiaris)
MEX3C [cytosol]
(Sus scrofa)
Mex3c [cytosol]
(Mus musculus)
Mex3c [cytosol]
(Rattus norvegicus)
mex-3 [cytosol]
(Caenorhabditis elegans)
Dmel\CG11360 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_057710.3
OpenTargets
ENSG00000176624
GeneCards
Q5U5Q3
HPA
ENSG00000176624-MEX3C
Ensembl
ENST00000406189
,
ENSP00000385610
,
ENSG00000176624
PRO
Q5U5Q3
Pharos - Targets
Q5U5Q3
PDB
5ZI6
,
5WWX
,
5WWZ
,
5WWW
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.564
3
UniProt:Q93009 USP7
2
USP7 [cytosol]
(R-HSA-8853511)
USP7 [nucleoplasm]
(R-HSA-3215278)
0.524
3
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