Reactome | LNX1 [cytosol]

LNX1 [cytosol]

Stable Identifier

R-HSA-8851641

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase LNX ecNumber6.3.2.-/ecNumber, LNX1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8TBB1 LNX1

Gene Names

LNX1, LNX, PDZRN2, UNQ574/PRO1136

Chain

chain:1-728

Reference Genes

BioGPS Gene:84708 LNX1

COSMIC (genes):LNX1 LNX1

CTD Gene:84708 LNX1

dbSNP Gene:84708 LNX1

ENSEMBL:ENSG00000072201 LNX1

HGNC:6657 LNX1

KEGG Gene (Homo sapiens):84708 LNX1

Monarch:84708 LNX1

NCBI Gene:84708 LNX1

OMIM:609732 LNX1

UCSC:Q8TBB1 LNX1

Reference Transcript

Other Identifiers

0006400152

0106040372

11730250_a_at

11730251_x_at

11750800_a_at

11759021_at

16975971

2235

223611_s_at

223612_s_at

2769349

2769350

2769351

2769352

2769354

2769355

2769356

2769358

2769359

2769361

2769362

2769363

2769364

2769365

2769370

2769371

2769372

2769373

2769376

2769377

2769378

2769379

2769380

2769403

3B76

58454_at

5H7R

5H7S

71091

8100362

84708

92105_s_at

A0A0B4J209

A_23_P213137

A_24_P54900

AAH22983

AAH34737

AAK15039

AAQ88692

AAY41000

AC058822

AC095040

AF237782

AK056823

AY358326

BAB71291

BC022983

BC034737

CCDS3492

CCDS47057

D6RAH9

D6RB76

ENSG00000072201

ENSP00000263925

ENSP00000302879

ENST00000263925

ENST00000263925.7

ENST00000306888

ENST00000306888.6

EntrezGene:84708

EntrezGene:LNX1

g13183072_3p_a_at

GE83457

GO:0003674

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0006464

GO:0006511

GO:0008150

GO:0009056

GO:0016567

GO:0016740

GO:0022607

GO:0030165

GO:0043167

GO:0046872

GO:0051260

GO:0065003

HGNC:6657

HPA002235

HPA071091

Hs.66295.1.A1_3p_a_at

ILMN_1713841

IPR001478

IPR001841

IPR013083

IPR017907

IPR018957

IPR036034

LNX1

LNX1-201

LNX1-202

MIM:609732

NM_001126328

NM_032622

NP_001119800

NP_116011

PF00097

PF00595

PH_hs_0004051

SM00184

SM00228

TC04001199.hg

UPI000002AD5F

UPI000012E7A6

XM_005265785

XM_017008776

XM_024454261

XM_024454262

XP_005265842

XP_016864265

XP_024310029

XP_024310030

Participant Of

hasCandidate

E3 ligases in proteasomal degradation [cytosol]

Inferred To

LNX1 [cytosol] (Bos taurus)

LNX1 [cytosol] (Caenorhabditis elegans)

LNX1 [cytosol] (Canis familiaris)

LNX1 [cytosol] (Danio rerio)

LNX1 [cytosol] (Drosophila melanogaster)

LNX1 [cytosol] (Gallus gallus)

LNX1 [cytosol] (Mus musculus)

LNX1 [cytosol] (Rattus norvegicus)

LNX1 [cytosol] (Sus scrofa)

LNX1 [cytosol] (Xenopus tropicalis)

Homologues of LNX1 [cytosol] (Caenorhabditis elegans)

Homologues of LNX1 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_116011.2, XP_005265842.1, NP_001119800.1, XP_016864265.1

OpenTargets

ENSG00000072201

GeneCards

Q8TBB1

PRO

Q8TBB1

PDB

3B76, 5H7R, 5H7S

HMDB Protein

HMDBP09319

Interactors (73)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96GX9 APIP	1	APIP [cytosol] (R-HSA-1237171)	0.764	8
UniProt:P21673 SAT1	1	SAT1 [cytosol] (R-HSA-351236)	0.764	8
UniProt:O75771 RAD51D	1	RAD51D [nucleoplasm] (R-HSA-216920)	0.718	6
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.696	5
UniProt:O95848 NUDT14	1	NUDT14 [cytosol] (R-HSA-6809220)	0.696	7
UniProt:Q719H9 KCTD1	1	KCTD1 [nucleoplasm] (R-HSA-8864339)	0.696	5
UniProt:Q9Y316 MEMO1	1	MEMO1 [cytosol] (R-HSA-6785630)	0.696	5
UniProt:Q13077 TRAF1	3	TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1 [cytosol] (R-HSA-5634163) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.666	6
UniProt:P49247 RPIA	2	RPIA [cytosol] (R-HSA-71304) RPIA A61V [cytosol] (R-HSA-5660009)	0.621	3
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848)	0.621	3
UniProt:P38159 RBMX	1	RBMX [nucleoplasm] (R-HSA-71939)	0.621	3
UniProt:Q92841 DDX17	2	SUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104) DDX17 [nucleoplasm] (R-HSA-3900090)	0.621	3
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.556	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	3
UniProt:P62937 PPIA	5	PPIA [secretory granule lumen] (R-HSA-6801400) PPIA [extracellular exosome] (R-HSA-6801538) PPIA [extracellular region] (R-HSA-173646) PPIA [ficolin-1-rich granule lumen] (R-HSA-6801391) PPIA [cytosol] (R-HSA-173123)	0.556	3
UniProt:Q53H54 TRMT12	1	TRMT12 [cytoplasm] (R-HSA-6782860)	0.556	3
UniProt:O75553 DAB1	2	p-Y198,220,232-DAB1 [cytosol] (R-HSA-8855227) DAB1 [cytosol] (R-HSA-8855236)	0.556	3
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.556	6
UniProt:Q6UWP7 LCLAT1	1	LCLAT1 [endoplasmic reticulum membrane] (R-HSA-1498783)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.556	3
UniProt:Q96QG7 MTMR9	1	MTMR9 [cytosol] (R-HSA-6809239)	0.556	3
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.556	3
UniProt:Q8WZA1 POMGNT1	6	POMGNT1 S550N [Golgi membrane] (R-HSA-5617094) POMGNT1 [Golgi membrane] (R-HSA-5617040) POMGNT1 R605Vfs29 [Golgi membrane] (R-HSA-5617081) POMGNT1 R63 [Golgi membrane] (R-HSA-5617033) POMGNT1 W475* [Golgi membrane] (R-HSA-5617097) POMGNT1 P493R [Golgi membrane] (R-HSA-5617048)	0.556	3
UniProt:Q15056 EIF4H	1	EIF4H [cytosol] (R-HSA-72591)	0.556	3
UniProt:Q8WXB1 METTL21A	1	METTL21A [nucleoplasm] (R-HSA-8876682)	0.556	3
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.488	2
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.488	2
UniProt:Q9Y4K3 TRAF6	8	K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.488	2
UniProt:Q9H2G4 TSPYL2	1	TSPYL2 [nucleoplasm] (R-HSA-535540)	0.488	2
UniProt:Q9Y2T1 AXIN2	4	Ub-RibC-AXIN2 [cytosol] (R-HSA-3640859) AXIN2 [cytosol] (R-HSA-3640821) RibC-AXIN2 [cytosol] (R-HSA-3640842) ub-AXIN2 [cytosol] (R-HSA-4641131)	0.488	2
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.488	2
UniProt:P11086 PNMT	1	PNMT [cytosol] (R-HSA-209831)	0.488	2
UniProt:Q9NWX6 THG1L	1	THG1L [cytosol] (R-HSA-6782438)	0.488	2
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.488	2
UniProt:Q86TI0 TBC1D1	2	p-S237-TBC1D1 [cytosol] (R-HSA-1454673) TBC1D1 [cytoplasmic vesicle membrane] (R-HSA-1454718)	0.488	2
UniProt:P55212 CASP6	5	CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.488	2
UniProt:P50458 LHX2	1	LHX2 [nucleoplasm] (R-HSA-9011100)	0.488	2
UniProt:Q14565 DMC1	1	DMC1 [nucleoplasm] (R-HSA-912490)	0.488	2
UniProt:Q9NP31 SH2D2A	1	SH2D2A [cytosol] (R-HSA-4420125)	0.488	2
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.488	2
UniProt:Q9UL46 PSME2	2	PSME2 [cytosol] (R-HSA-68814) PSME2 [nucleoplasm] (R-HSA-174350)	0.488	2
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.488	2
UniProt:P49327 FASN	3	FASN [cytosol] (R-HSA-54659) FASN [cytosol] (R-HSA-199233) decanoyl-FASN [cytosol] (R-HSA-5655935)	0.488	2
UniProt:Q9Y3M2 CBY1	3	pS20-CBY1 [nucleoplasm] (R-HSA-3769356) CBY1 [nucleoplasm] (R-HSA-3769210) pS20-CBY1 [cytosol] (R-HSA-3769354)	0.488	2
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.488	2
UniProt:P19474 TRIM21	1	TRIM21 [cytosol] (R-HSA-976051)	0.488	2
UniProt:O14561 NDUFAB1	3	PPANT-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-8933545) NDUFAB1 [mitochondrial inner membrane] (R-HSA-163925) Mal-PPANT-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-8934586)	0.488	2
UniProt:Q13490 BIRC2	5	BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.488	2
UniProt:P35638 DDIT3	1	DDIT3 [nucleoplasm] (R-HSA-381110)	0.488	2
UniProt:Q13094 LCP2	2	p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175) LCP2 [cytosol] (R-HSA-202306)	0.488	2
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.488	2
UniProt:P84103 SRSF3	1	SRSF3 [nucleoplasm] (R-HSA-72035)	0.488	2
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.488	2
UniProt:P47897 QARS	2	QARS [mitochondrial matrix] (R-HSA-379592) QARS [cytosol] (R-HSA-379615)	0.488	2
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.488	2
UniProt:O00401 WASL	4	N-WASP [cytosol] (R-HSA-201873) p-Y256-WASL [cytosol] (R-HSA-2197672) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.488	2
UniProt:Q13370 PDE3B	2	p-S295-PDE3B [cytosol] (R-HSA-162419) PDE3B [cytosol] (R-HSA-162348)	0.488	2
UniProt:P52333 JAK3	5	JAK3 [endosome] (R-HSA-8983184) p-Y904,939-JAK3 [plasma membrane] (R-HSA-8985978) p-JAK3 [cytosol] (R-HSA-8982856) p-Y-JAK3 [cytosol] (R-HSA-9006854) JAK3 [cytosol] (R-HSA-451893)	0.488	2
UniProt:O75496 GMNN	2	GMNN [cytosol] (R-HSA-68534) GMNN [nucleoplasm] (R-HSA-113554)	0.488	2
UniProt:P12814 ACTN1	3	ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [cytosol] (R-HSA-354096) ACTN1 [extracellular region] (R-HSA-349722)	0.488	2
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.488	2
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.488	2
UniProt:P52597 HNRNPF	2	HNRNPF [plasma membrane] (R-HSA-8950714) HNRNPF [nucleoplasm] (R-HSA-71937)	0.488	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.488	2
UniProt:O14544 SOCS6	1	SOCS6 [cytosol] (R-HSA-1469969)	0.488	2
UniProt:Q96G04 EEF2KMT	1	EEF2KMT [cytosol] (R-HSA-8876690)	0.488	2
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.488	2
UniProt:Q13114 TRAF3	5	TRAF3 [cytosol] (R-HSA-914241) K63polyUb-TRAF3 [cytosol] (R-HSA-936402) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) K48polyUb-TRAF3 [cytosol] (R-HSA-5668444) TRAF3 R118W [cytosol] (R-HSA-5602321)	0.488	2
UniProt:Q9GZV8 PRDM14	1	PRDM14 [nucleoplasm] (R-HSA-1112608)	0.488	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.488	4
UniProt:P55072 VCP	8	VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [nucleoplasm] (R-HSA-5643745) VCP [cytosol] (R-HSA-1181251) VCP [secretory granule lumen] (R-HSA-6801039) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425)	0.488	2
UniProt:Q5VWX1 KHDRBS2	2	p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031) KHDRBS2 [nucleoplasm] (R-HSA-8849028)	0.488	2
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.463	2