Reactome | LNX1 [cytosol]

LNX1 [cytosol]

Stable Identifier

R-HSA-8851641

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase LNX ecNumber6.3.2.-/ecNumber, LNX1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q8TBB1 LNX1

Gene Names

LNX1, LNX, PDZRN2, UNQ574/PRO1136

Chain

chain:1-728

Reference Genes

BioGPS Gene:84708 LNX1

COSMIC (genes):LNX1 LNX1

CTD Gene:84708 LNX1

dbSNP Gene:84708 LNX1

ENSEMBL:ENSG00000072201 LNX1

HGNC:6657 LNX1

KEGG Gene (Homo sapiens):84708 LNX1

Monarch:84708 LNX1

NCBI Gene:84708 LNX1

OMIM:609732 LNX1

UCSC:Q8TBB1 LNX1

Reference Transcript

Other Identifiers

0006400152

0106040372

11730250_a_at

11730251_x_at

11750800_a_at

11759021_at

16975971

223611_s_at

223612_s_at

2769349

2769350

2769351

2769352

2769354

2769355

2769356

2769358

2769359

2769361

2769362

2769363

2769364

2769365

2769370

2769371

2769372

2769373

2769376

2769377

2769378

2769379

2769403

58454_at

8100362

84708

92105_s_at

A_23_P213137

A_24_P54900

GE83457

GO:0003674

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0006464

GO:0006511

GO:0008150

GO:0009056

GO:0016567

GO:0016740

GO:0030165

GO:0042802

GO:0043167

GO:0046872

HMNXSV003041278

Hs.66295.1.A1_3p_a_at

ILMN_1713841

PH_hs_0004051

TC04001199.hg

g13183072_3p_a_at

Participates

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

Patj [cytosol] (Drosophila melanogaster)

lnx1 [cytosol] (Danio rerio)

lnx1 [cytosol] (Xenopus tropicalis)

LNX1 [cytosol] (Canis familiaris)

LNX1 [cytosol] (Gallus gallus)

LNX1 [cytosol] (Sus scrofa)

Homologues of LNX1 [cytosol] (Caenorhabditis elegans)

Homologues of LNX1 [cytosol] (Drosophila melanogaster)

mpz-1 [cytosol] (Caenorhabditis elegans)

Lnx1 [cytosol] (Mus musculus)

Lnx1 [cytosol] (Rattus norvegicus)

a [cytosol] (Drosophila melanogaster)

frm-5.2 [cytosol] (Caenorhabditis elegans)

inaD [cytosol] (Drosophila melanogaster)

frm-5.1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

XP_005265842.1, NP_116011.2, XP_016864265.1, NP_001119800.1

OpenTargets

ENSG00000072201

GeneCards

Q8TBB1

HPA

ENSG00000072201-LNX1

Ensembl

ENSP00000302879, ENST00000263925, ENST00000306888, ENSP00000263925, ENSG00000072201

PRO

Q8TBB1

Pharos - Targets

Q8TBB1

HMDB Protein

HMDBP09319

PDB

5H7R, 3B76, 5H7S

Interactors (82)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21673 SAT1	1	SAT1 [cytosol] (R-HSA-351236)	0.83	8
UniProt:Q96GX9 APIP	1	APIP [cytosol] (R-HSA-1237171)	0.83	11
UniProt:Q719H9 KCTD1	1	KCTD1 [nucleoplasm] (R-HSA-8864339)	0.781	7
UniProt:O75553 DAB1	2	p-Y198,220,232-DAB1 [cytosol] (R-HSA-8855227) DAB1 [cytosol] (R-HSA-8855236)	0.742	5
UniProt:Q96QG7 MTMR9	1	MTMR9 [cytosol] (R-HSA-6809239)	0.742	5
UniProt:P49247 RPIA	2	RPIA [cytosol] (R-HSA-71304) RPIA A61V [cytosol] (R-HSA-5660009)	0.742	5
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [cytosol] (R-HSA-66370)	0.742	5
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.718	6
UniProt:O75771 RAD51D	1	RAD51D [nucleoplasm] (R-HSA-216920)	0.718	6
UniProt:O95848 NUDT14	1	NUDT14 [cytosol] (R-HSA-6809220)	0.718	8
UniProt:Q9Y316 MEMO1	1	MEMO1 [cytosol] (R-HSA-6785630)	0.718	6
UniProt:Q13077 TRAF1	3	TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204) TRAF1 [cytosol] (R-HSA-5634163)	0.696	7
UniProt:Q92841 DDX17	2	DDX17 [nucleoplasm] (R-HSA-3900090) SUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104)	0.666	4
UniProt:Q8WXB1 METTL21A	1	METTL21A [nucleoplasm] (R-HSA-8876682)	0.666	4
UniProt:P38159 RBMX	2	RBMX [cytosol] (R-HSA-9715135) RBMX [nucleoplasm] (R-HSA-71939)	0.666	4
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.666	4
UniProt:P55072 VCP	8	VCP [secretory granule lumen] (R-HSA-6801039) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [extracellular region] (R-HSA-6806191) Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [cytosol] (R-HSA-1181251) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [nucleoplasm] (R-HSA-5643745)	0.666	4
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.666	4
UniProt:Q15056 EIF4H	1	EIF4H [cytosol] (R-HSA-72591)	0.666	4
UniProt:Q8WZA1 POMGNT1	6	POMGNT1 [Golgi membrane] (R-HSA-5617040) POMGNT1 R63* [Golgi membrane] (R-HSA-5617033) POMGNT1 W475* [Golgi membrane] (R-HSA-5617097) POMGNT1 P493R [Golgi membrane] (R-HSA-5617048) POMGNT1 S550N [Golgi membrane] (R-HSA-5617094) POMGNT1 R605Vfs*29 [Golgi membrane] (R-HSA-5617081)	0.666	4
UniProt:Q9UL46 PSME2	2	PSME2 [cytosol] (R-HSA-68814) PSME2 [nucleoplasm] (R-HSA-174350)	0.556	3
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.556	3
UniProt:P52597 HNRNPF	2	HNRNPF [nucleoplasm] (R-HSA-71937) HNRNPF [plasma membrane] (R-HSA-8950714)	0.556	3
UniProt:P19474 TRIM21	1	TRIM21 [cytosol] (R-HSA-976051)	0.556	3
UniProt:P49327 FASN	3	FASN [cytosol] (R-HSA-199233) decanoyl-FASN [cytosol] (R-HSA-5655935) FASN [cytosol] (R-HSA-54659)	0.556	3
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.556	3
UniProt:Q9Y2T1 AXIN2	4	ub-AXIN2 [cytosol] (R-HSA-4641131) RibC-AXIN2 [cytosol] (R-HSA-3640842) AXIN2 [cytosol] (R-HSA-3640821) Ub-RibC-AXIN2 [cytosol] (R-HSA-3640859)	0.556	3
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.556	3
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.556	3
UniProt:P37840 SNCA	4	SNCA [cytosol] (R-HSA-5658500) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569) Ub-SNCA [cytosol] (R-HSA-5660754)	0.556	3
UniProt:Q6UWP7 LCLAT1	1	LCLAT1 [endoplasmic reticulum membrane] (R-HSA-1498783)	0.556	3
UniProt:Q9GZV8 PRDM14	1	PRDM14 [nucleoplasm] (R-HSA-1112608)	0.556	5
UniProt:P12814 ACTN1	3	ACTN1 [cytosol] (R-HSA-354096) ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [extracellular region] (R-HSA-349722)	0.556	3
UniProt:P35638 DDIT3	1	DDIT3 [nucleoplasm] (R-HSA-381110)	0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:P47897 QARS1	2	QARS [mitochondrial matrix] (R-HSA-379592) QARS [cytosol] (R-HSA-379615)	0.556	3
UniProt:P84103 SRSF3	1	SRSF3 [nucleoplasm] (R-HSA-72035)	0.556	3
UniProt:Q9NS75 CYSLTR2	2	CYSLTR1,2 [plasma membrane] (R-HSA-163618) CYSLTR2 [plasma membrane] (R-HSA-416399)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:Q96G04 EEF2KMT	1	EEF2KMT [cytosol] (R-HSA-8876690)	0.556	3
UniProt:O14561 NDUFAB1	3	NDUFAB1 [mitochondrial inner membrane] (R-HSA-163925) Mal-PPANT-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-8934586) PPANT-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-8933545)	0.556	3
UniProt:P38919 EIF4A3	2	EIF4A3 [cytosol] (R-HSA-927868) EIF4A3 [nucleoplasm] (R-HSA-8849149)	0.556	3
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q9Y4K3 TRAF6	8	K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) TRAF6 [cytosol] (R-HSA-166366)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.556	3
UniProt:Q13490 BIRC2	5	BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913)	0.556	3
UniProt:Q9NWX6 THG1L	1	THG1L [cytosol] (R-HSA-6782438)	0.556	3
UniProt:Q13370 PDE3B	2	PDE3B [cytosol] (R-HSA-162348) p-S295-PDE3B [cytosol] (R-HSA-162419)	0.556	3
UniProt:P55212 CASP6	5	CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:Q14565 DMC1	1	DMC1 [nucleoplasm] (R-HSA-912490)	0.556	3
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.556	3
UniProt:P50458 LHX2	1	LHX2 [nucleoplasm] (R-HSA-9011100)	0.556	3
UniProt:P62937 PPIA	5	PPIA [extracellular exosome] (R-HSA-6801538) PPIA [secretory granule lumen] (R-HSA-6801400) PPIA [extracellular region] (R-HSA-173646) PPIA [ficolin-1-rich granule lumen] (R-HSA-6801391) PPIA [cytosol] (R-HSA-173123)	0.556	3
UniProt:P11086 PNMT	1	PNMT [cytosol] (R-HSA-209831)	0.556	3
UniProt:O75496 GMNN	2	GMNN [nucleoplasm] (R-HSA-113554) GMNN [cytosol] (R-HSA-68534)	0.556	3
UniProt:P12931 SRC	6	MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) p-Y416-SRC [cytosol] (R-HSA-8964276) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.556	6
UniProt:Q9Y3M2 CBY1	3	CBY1 [nucleoplasm] (R-HSA-3769210) pS20-CBY1 [cytosol] (R-HSA-3769354) pS20-CBY1 [nucleoplasm] (R-HSA-3769356)	0.556	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:Q9H2G4 TSPYL2	1	TSPYL2 [nucleoplasm] (R-HSA-535540)	0.556	3
UniProt:Q13114 TRAF3	5	K48polyUb-TRAF3 [cytosol] (R-HSA-5668444) TRAF3 [cytosol] (R-HSA-914241) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 R118W [cytosol] (R-HSA-5602321) K63polyUb-TRAF3 [cytosol] (R-HSA-936402)	0.556	3
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.556	5
UniProt:Q13094 LCP2	2	LCP2 [cytosol] (R-HSA-202306) p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175)	0.556	3
UniProt:P35240 NF2	1	NF2 [plasma membrane] (R-HSA-5669168)	0.556	3
UniProt:Q86TI0 TBC1D1	2	TBC1D1 [cytoplasmic vesicle membrane] (R-HSA-1454718) p-S237-TBC1D1 [cytosol] (R-HSA-1454673)	0.556	3
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609)	0.556	3
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.556	3
UniProt:Q53H54 TRMT12	1	TRMT12 [cytoplasm] (R-HSA-6782860)	0.556	3
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.556	3
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.553	2
UniProt:O75525 KHDRBS3	2	p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035) KHDRSB3 [nucleoplasm] (R-HSA-8849040)	0.553	2
UniProt:O14544 SOCS6	1	SOCS6 [cytosol] (R-HSA-1469969)	0.488	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.488	4
UniProt:Q9NP31 SH2D2A	1	SH2D2A [cytosol] (R-HSA-4420125)	0.488	2
UniProt:P52333 JAK3	6	p-JAK3 [cytosol] (R-HSA-8982856) JAK3 [cytosol] (R-HSA-451893) JAK3 [endosome] (R-HSA-8983184) p-Y-JAK3 [cytosol] (R-HSA-9006854) p-Y980 JAK3 [cytosol] (R-HSA-9701438) p-Y904,939-JAK3 [plasma membrane] (R-HSA-8985978)	0.488	2
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.463	2

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