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LNX1 [cytosol]
Stable Identifier
R-HSA-8851641
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase LNX ecNumber6.3.2.-/ecNumber, LNX1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LNX1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TBB1 LNX1
Gene Names
LNX1, LNX, PDZRN2, UNQ574/PRO1136
Chain
chain:1-728
Reference Genes
BioGPS Gene:84708 LNX1
COSMIC (genes):LNX1 LNX1
CTD Gene:84708 LNX1
dbSNP Gene:84708 LNX1
ENSEMBL:ENSG00000072201 LNX1
HGNC:6657 LNX1
KEGG:hsa:84708 LNX1
Monarch:84708 LNX1
NCBI Gene:84708 LNX1
OMIM:609732 LNX1
UCSC:Q8TBB1 LNX1
Reference Transcript
RefSeq:XM_017008776.1 LNX1
RefSeq:NM_001126328.2 LNX1
RefSeq:NM_032622.2 LNX1
RefSeq:XM_005265785.4 LNX1
Other Identifiers
11730250_a_at
11730251_x_at
11750800_a_at
11759021_at
16975971
223611_PM_s_at
223611_s_at
223612_PM_s_at
223612_s_at
2769349
2769350
2769351
2769352
2769354
2769355
2769356
2769358
2769359
2769360
2769361
2769362
2769363
2769364
2769365
2769370
2769371
2769372
2769373
2769376
2769377
2769378
2769379
2769380
2769384
2769385
2769386
2769390
2769392
2769394
2769403
58454_at
8100362
84708
92105_s_at
A_23_P213137
A_24_P54900
GE83457
GO:0003824
GO:0004842
GO:0005515
GO:0005737
GO:0006511
GO:0016567
GO:0016740
GO:0030165
GO:0034330
GO:0042802
GO:0046872
GO:0060074
GO:0098686
GO:0098794
GO:0140096
HMNXSV003041278
Hs.66295.1.A1_3p_a_at
ILMN_1713841
PH_hs_0004051
TC04001199.hg
g13183072_3p_a_at
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
Patj [cytosol]
(Drosophila melanogaster)
lnx1 [cytosol]
(Xenopus tropicalis)
LNX1 [cytosol]
(Bos taurus)
LNX1 [cytosol]
(Caenorhabditis elegans)
LNX1 [cytosol]
(Canis familiaris)
LNX1 [cytosol]
(Gallus gallus)
LNX1 [cytosol]
(Sus scrofa)
Homologues of LNX1 [cytosol]
(Caenorhabditis elegans)
Homologues of LNX1 [cytosol]
(Drosophila melanogaster)
mpz-1 [cytosol]
(Caenorhabditis elegans)
Lnx1 [cytosol]
(Mus musculus)
Lnx1 [cytosol]
(Rattus norvegicus)
a [cytosol]
(Drosophila melanogaster)
frm-5.2 [cytosol]
(Caenorhabditis elegans)
inaD [cytosol]
(Drosophila melanogaster)
frm-5.1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_005265842.1
,
XP_016864265.1
,
NP_001119800.1
,
NP_116011.2
OpenTargets
ENSG00000072201
ENSEMBL
ENSP00000263925
,
ENSP00000302879
,
ENST00000306888
,
ENST00000263925
IntEnz
2.3.2.27
HPA
ENSG00000072201-LNX1
PRO
Q8TBB1
Pharos - Targets
Q8TBB1
HMDB Protein
HMDBP09319
PDB
5H7S
,
5H7R
,
3B76
Interactors (87)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P21673 SAT1
1
SAT1 [cytosol]
(R-HSA-351236)
0.83
8
UniProt:Q96GX9 APIP
1
APIP [cytosol]
(R-HSA-1237171)
0.83
11
UniProt:P55072 VCP
8
VCP [cytosol]
(R-HSA-1181251)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
0.781
7
UniProt:Q719H9 KCTD1
1
KCTD1 [nucleoplasm]
(R-HSA-8864339)
0.781
7
UniProt:O75553 DAB1
2
DAB1 [cytosol]
(R-HSA-8855236)
p-Y198,220,232-DAB1 [cytosol]
(R-HSA-8855227)
0.742
5
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.742
5
UniProt:Q96QG7 MTMR9
1
MTMR9 [cytosol]
(R-HSA-6809239)
0.742
5
UniProt:P49247 RPIA
2
RPIA [cytosol]
(R-HSA-71304)
RPIA A61V [cytosol]
(R-HSA-5660009)
0.742
5
UniProt:Q9Y230 RUVBL2
1
RUVBL2 [nucleoplasm]
(R-HSA-418321)
0.718
6
UniProt:O75771 RAD51D
1
RAD51D [nucleoplasm]
(R-HSA-216920)
0.718
6
UniProt:Q9Y316 MEMO1
1
MEMO1 [cytosol]
(R-HSA-6785630)
0.718
6
UniProt:O95848 NUDT14
1
NUDT14 [cytosol]
(R-HSA-6809220)
0.718
8
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.696
7
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.666
4
UniProt:Q7Z3S9 NOTCH2NLA
3
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
NOTCH2NLA(1-?) [extracellular region]
(R-HSA-9911493)
NOTCH2NLA(?-236) [extracellular region]
(R-HSA-9911490)
0.666
4
UniProt:Q8WZA1 POMGNT1
6
POMGNT1 [Golgi membrane]
(R-HSA-5617040)
POMGNT1 S550N [Golgi membrane]
(R-HSA-5617094)
POMGNT1 R605Vfs*29 [Golgi membrane]
(R-HSA-5617081)
POMGNT1 R63* [Golgi membrane]
(R-HSA-5617033)
POMGNT1 W475* [Golgi membrane]
(R-HSA-5617097)
POMGNT1 P493R [Golgi membrane]
(R-HSA-5617048)
0.666
4
UniProt:Q8NC69 KCTD6
1
KCTD6 [cytosol]
(R-HSA-8863321)
0.666
4
UniProt:Q8WXB1 METTL21A
1
METTL21A [nucleoplasm]
(R-HSA-8876682)
0.666
4
UniProt:Q15056 EIF4H
1
EIF4H [cytosol]
(R-HSA-72591)
0.666
4
UniProt:Q92841 DDX17
2
monoSUMO1-K50-DDX17 [nucleoplasm]
(R-HSA-3900104)
DDX17 [nucleoplasm]
(R-HSA-3900090)
0.666
4
UniProt:P61289 PSME3
1
PSME3 [cytosol]
(R-HSA-68816)
0.556
3
UniProt:Q9NWX6 THG1L
1
THG1L [cytosol]
(R-HSA-6782438)
0.556
3
UniProt:Q86TI0 TBC1D1
2
TBC1D1 [cytoplasmic vesicle membrane]
(R-HSA-1454718)
p-S237-TBC1D1 [cytosol]
(R-HSA-1454673)
0.556
3
UniProt:Q96ES7 SGF29
1
SGF29 [nucleoplasm]
(R-HSA-3662279)
0.556
3
UniProt:P12814 ACTN1
3
ACTN1 [cytosol]
(R-HSA-354096)
ACTN1 [platelet alpha granule lumen]
(R-HSA-349724)
ACTN1 [extracellular region]
(R-HSA-349722)
0.556
3
UniProt:Q14565 DMC1
1
DMC1 [nucleoplasm]
(R-HSA-912490)
0.556
3
UniProt:P62306 SNRPF
2
SNRPF [cytosol]
(R-HSA-191852)
SNRPF [nucleoplasm]
(R-HSA-71907)
0.556
3
UniProt:P55212 CASP6
5
CASP6(194-293) [cytosol]
(R-HSA-266128)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
0.556
3
UniProt:P21580 TNFAIP3
1
TNFAIP3 [cytosol]
(R-HSA-688989)
0.556
3
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.556
3
UniProt:Q9UL46 PSME2
2
PSME2 [nucleoplasm]
(R-HSA-174350)
PSME2 [cytosol]
(R-HSA-68814)
0.556
3
UniProt:Q9H2G4 TSPYL2
1
TSPYL2 [nucleoplasm]
(R-HSA-535540)
0.556
3
UniProt:P12931 SRC
6
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
0.556
6
UniProt:Q92917 GPKOW
1
GPKOW [nucleoplasm]
(R-HSA-8850839)
0.556
5
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
UniProt:P62937 PPIA
5
PPIA [extracellular exosome]
(R-HSA-6801538)
PPIA [ficolin-1-rich granule lumen]
(R-HSA-6801391)
PPIA [extracellular region]
(R-HSA-173646)
PPIA [secretory granule lumen]
(R-HSA-6801400)
PPIA [cytosol]
(R-HSA-173123)
0.556
3
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.556
3
UniProt:O14744 PRMT5
3
PRMT5 [cytosol]
(R-HSA-191876)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
0.556
3
UniProt:P35240 NF2
1
NF2 [plasma membrane]
(R-HSA-5669168)
0.556
3
UniProt:Q13490 BIRC2
5
BIRC2 [cytosol]
(R-HSA-50847)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
0.556
3
UniProt:Q9Y6D9 MAD1L1
1
MAD1L1 [cytosol]
(R-HSA-141433)
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.556
3
UniProt:Q9NS75 CYSLTR2
1
CYSLTR2 [plasma membrane]
(R-HSA-416399)
0.556
3
UniProt:P47897 QARS1
2
QARS [cytosol]
(R-HSA-379615)
QARS [mitochondrial matrix]
(R-HSA-379592)
0.556
3
UniProt:P38919 EIF4A3
2
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
EIF4A3 [cytosol]
(R-HSA-927868)
0.556
3
UniProt:P62191 PSMC1
2
PSMC1 [cytosol]
(R-HSA-68768)
PSMC1 [nucleoplasm]
(R-HSA-174338)
0.556
3
UniProt:Q13094 LCP2
2
p-Y113,128,145-LCP2 [cytosol]
(R-HSA-202175)
LCP2 [cytosol]
(R-HSA-202306)
0.556
3
UniProt:P53365 ARFIP2
1
ARFIP2 [cytosol]
(R-HSA-6813848)
0.556
3
UniProt:P35638 DDIT3
1
DDIT3 [nucleoplasm]
(R-HSA-381110)
0.556
3
UniProt:Q13370 PDE3B
2
p-S295-PDE3B [cytosol]
(R-HSA-162419)
PDE3B [cytosol]
(R-HSA-162348)
0.556
3
UniProt:O14561 NDUFAB1
4
octanoyl-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-9857608)
NDUFAB1 [mitochondrial inner membrane]
(R-HSA-163925)
PPANT-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-8933545)
Mal-PPANT-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-8934586)
0.556
3
UniProt:Q15742 NAB2
1
NAB2 [nucleoplasm]
(R-HSA-9612177)
0.556
3
UniProt:P04271 S100B
1
S100B [extracellular region]
(R-HSA-879433)
0.556
3
UniProt:O75496 GMNN
2
GMNN [nucleoplasm]
(R-HSA-113554)
PolyUb-GMNN [nucleoplasm]
(R-HSA-68585)
0.556
3
UniProt:P52597 HNRNPF
2
HNRNPF [nucleoplasm]
(R-HSA-71937)
HNRNPF [plasma membrane]
(R-HSA-8950714)
0.556
3
UniProt:P84103 SRSF3
1
SRSF3 [nucleoplasm]
(R-HSA-72035)
0.556
3
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
3
UniProt:Q53H54 TRMT12
1
TRMT12 [cytoplasm]
(R-HSA-6782860)
0.556
3
UniProt:P19474 TRIM21
1
TRIM21 [cytosol]
(R-HSA-976051)
0.556
3
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.556
3
UniProt:Q96G04 EEF2KMT
1
EEF2KMT [cytosol]
(R-HSA-8876690)
0.556
3
UniProt:Q9H1K1 ISCU
1
ISCU [cytosol]
(R-HSA-9771680)
0.556
3
UniProt:Q6UWP7 LCLAT1
1
LCLAT1 [endoplasmic reticulum membrane]
(R-HSA-1498783)
0.556
3
UniProt:Q9Y3M2 CBY1
3
CBY1 [nucleoplasm]
(R-HSA-3769210)
pS20-CBY1 [nucleoplasm]
(R-HSA-3769356)
pS20-CBY1 [cytosol]
(R-HSA-3769354)
0.556
3
UniProt:Q13114 TRAF3
4
K63polyUb-TRAF3 [cytosol]
(R-HSA-936402)
TRAF3 [cytosol]
(R-HSA-914241)
K48polyUb-TRAF3 [cytosol]
(R-HSA-936556)
TRAF3 R118W [cytosol]
(R-HSA-5602321)
0.556
3
UniProt:Q9GZV8 PRDM14
1
PRDM14 [nucleoplasm]
(R-HSA-1112608)
0.556
5
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
0.556
3
UniProt:P50458 LHX2
1
LHX2 [nucleoplasm]
(R-HSA-9011100)
0.556
3
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.556
3
UniProt:P37840 SNCA
5
SNCA [cytosol]
(R-HSA-5658500)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
Ub-SNCA [cytosol]
(R-HSA-5660754)
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
0.556
3
UniProt:O96006 ZBED1
1
ZBED1 [nucleoplasm]
(R-HSA-8956376)
0.556
3
UniProt:P11086 PNMT
1
PNMT [cytosol]
(R-HSA-209831)
0.556
3
UniProt:Q9Y2T1 AXIN2
4
AXIN2 [cytosol]
(R-HSA-3640821)
ub-AXIN2 [cytosol]
(R-HSA-4641131)
RibC-AXIN2 [cytosol]
(R-HSA-3640842)
Ub-RibC-AXIN2 [cytosol]
(R-HSA-3640859)
0.556
3
UniProt:Q92530 PSMF1
1
PSMF1 [cytosol]
(R-HSA-68818)
0.556
3
UniProt:O76003 GLRX3
1
GLRX3 [cytosol]
(R-HSA-5691202)
0.556
3
UniProt:P0DPK4 NOTCH2NLC
1
NOTCH2NLC [extracellular region]
(R-HSA-9908932)
0.556
3
UniProt:P49327 FASN
3
FASN [cytosol]
(R-HSA-54659)
decanoyl-FASN [cytosol]
(R-HSA-5655935)
FASN [cytosol]
(R-HSA-199233)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:Q5VWX1 KHDRBS2
2
KHDRBS2 [nucleoplasm]
(R-HSA-8849028)
p-Y-KHDRBS2 [nucleoplasm]
(R-HSA-8849031)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
6
UniProt:O75525 KHDRBS3
2
KHDRSB3 [nucleoplasm]
(R-HSA-8849040)
p-Y-KHDRSB3 [nucleoplasm]
(R-HSA-8849035)
0.553
2
UniProt:Q07955 SRSF1
1
SRSF1 [nucleoplasm]
(R-HSA-72031)
0.553
2
UniProt:P52333 JAK3
6
JAK3 [cytosol]
(R-HSA-451893)
p-Y-JAK3 [cytosol]
(R-HSA-9006854)
p-JAK3 [cytosol]
(R-HSA-8982856)
JAK3 [endosome]
(R-HSA-8983184)
p-Y904,939-JAK3 [plasma membrane]
(R-HSA-8985978)
p-Y980 JAK3 [cytosol]
(R-HSA-9701438)
0.488
2
UniProt:Q9NP31 SH2D2A
1
SH2D2A [cytosol]
(R-HSA-4420125)
0.488
2
UniProt:O75791 GRAP2
1
GRAP2 [cytosol]
(R-HSA-202367)
0.488
4
UniProt:O14544 SOCS6
1
SOCS6 [cytosol]
(R-HSA-1469969)
0.488
2
UniProt:P49757 NUMB
1
NUMB [plasma membrane]
(R-HSA-443595)
0.463
2
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