Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
RNF126 [cytosol]
Stable Identifier
R-HSA-8851642
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
fullName evidence="12"E3 ubiquitin-protein ligase RNF126 ecNumber evidence="4 8"6.3.2.-/ecNumber, RN126_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF126 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF126 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF126 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF126 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF126 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF126 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF126 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF126 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF126 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF126 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BV68 RNF126
Gene Names
RNF126
Chain
initiator methionine:, chain:2-311
Reference Genes
BioGPS Gene:55658 RNF126
COSMIC (genes):RNF126 RNF126
CTD Gene:55658 RNF126
dbSNP Gene:55658 RNF126
ENSEMBL:ENSG00000070423 RNF126
HGNC:21151 RNF126
KEGG:hsa:55658 RNF126
Monarch:55658 RNF126
NCBI Gene:55658 RNF126
OMIM:615177 RNF126
UCSC:Q9BV68 RNF126
Reference Transcript
RefSeq:NM_194460.2 RNF126
Other Identifiers
11745065_x_at
16866479
205748_3p_s_at
205748_PM_s_at
205748_s_at
215031_3p_x_at
215031_PM_x_at
215031_x_at
223332_3p_x_at
223332_PM_x_at
223332_x_at
3728077
3728078
3728080
3844702
3844703
3844705
3844706
3844707
3844708
3844709
3844710
3844711
3844712
3844714
3844715
3844716
3844717
3844718
3844719
3844720
3844721
3844722
3844723
3844724
3844725
3844732
3844734
3844735
39258_at
51159_f_at
55658
64906_at
8032076
A_23_P314086
A_33_P3270102
GE55548
GO:0003824
GO:0005154
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006511
GO:0006513
GO:0016192
GO:0016567
GO:0016740
GO:0030163
GO:0035519
GO:0042059
GO:0042127
GO:0042147
GO:0043161
GO:0043162
GO:0043226
GO:0044314
GO:0046872
GO:0061630
GO:0070534
GO:0070936
GO:0071629
GO:0140096
GO:1905168
HMNXSV003004020
Hs.69554.2.S1_3p_a_at
ILMN_1669572
ILMN_1790741
PH_hs_0028938
TC19000988.hg
g12655172_3p_a_at
g12655172_3p_x_at
g8923521_3p_s_at
g8923521_3p_x_at
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
rnf-126 [cytosol]
(Caenorhabditis elegans)
Rnf126 [cytosol]
(Rattus norvegicus)
RNF126 [cytosol]
(Bos taurus)
RNF126 [cytosol]
(Dictyostelium discoideum)
RNF126 [cytosol]
(Mus musculus)
RNF126 [cytosol]
(Sus scrofa)
RNF126 [cytosol]
(Xenopus tropicalis)
Iru [cytosol]
(Drosophila melanogaster)
rnf126 [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_919442.1
ENSEMBL
ENST00000292363
,
ENSP00000292363
OpenTargets
ENSG00000070423
HPA
ENSG00000070423-RNF126
PRO
Q9BV68
Pharos - Targets
Q9BV68
PDB
2N9P
,
2N9O
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51668 UBE2D1
3
UBE2D1 [cytosol]
(R-HSA-174236)
UBE2D1 [nucleoplasm]
(R-HSA-174197)
Ub-C85-UBE2D1 [cytosol]
(R-HSA-8864160)
0.817
7
UniProt:P61077 UBE2D3
3
Ub-C85-UBE2D3 [cytosol]
(R-HSA-8864191)
UBE2D3 [cytosol]
(R-HSA-934630)
UBE2D3 [nucleoplasm]
(R-HSA-205341)
0.712
4
UniProt:P05090 APOD
1
APOD [extracellular region]
(R-HSA-5216199)
0.527
2
UniProt:Q13309 SKP2
3
SKP2 [nucleoplasm]
(R-HSA-975554)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [cytosol]
(R-HSA-975495)
0.527
2
UniProt:Q14894 CRYM
1
CRYM [peroxisomal matrix]
(R-HSA-5693333)
0.527
2
UniProt:P16260 SLC25A16
1
SLC25A16 [mitochondrial inner membrane]
(R-HSA-199229)
0.527
2
UniProt:P0CG47 UBB
20
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-109-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-185-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-181-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
0.527
2
UniProt:Q8NFJ9 BBS1
1
BBS1 [cytosol]
(R-HSA-5617640)
0.508
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text