Reactome | BTBD1 [cytosol]

BTBD1 [cytosol]

Stable Identifier

R-HSA-8851650

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

BTB/POZ domain-containing protein 1, BTBD1_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        BTBD1 [cytosol] (Homo sapiens)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        BTBD1 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        BTBD1 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        BTBD1 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        BTBD1 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        BTBD1 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        BTBD1 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        BTBD1 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        BTBD1 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        BTBD1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H0C5 BTBD1

Gene Names

BTBD1, C15orf1, NS5ATP8

Chain

chain:1-482

Reference Genes

BioGPS Gene:53339 BTBD1

COSMIC (genes):BTBD1 BTBD1

CTD Gene:53339 BTBD1

dbSNP Gene:53339 BTBD1

ENSEMBL:ENSG00000064726 BTBD1

ENSEMBL_homo_sapiens_GENE:ENSG00000064726.10 BTBD1

HGNC:1120 BTBD1

KEGG Gene (Homo sapiens):53339 BTBD1

Monarch:53339 BTBD1

NCBI Gene:53339 BTBD1

OMIM:608530 BTBD1

UCSC:Q9H0C5 BTBD1

Reference Transcript

Other Identifiers

11716590_s_at

11716591_a_at

11716592_s_at

11716593_x_at

11716594_a_at

11741494_a_at

16812717

217945_PM_at

217945_at

3636471

3636472

3636473

3636474

3636475

3636478

3636479

3636484

3636487

3636488

3636491

3636492

3636493

3636494

3636495

3636496

3636497

45307_at

53339

7991057

GE55606

GO:0000932

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0007517

GO:0016567

GO:0022008

GO:0030154

GO:0032991

GO:0036211

GO:0036464

GO:0042802

GO:0043226

GO:0043393

GO:0048856

GO:0097602

HMNXSV003003264

HMNXSV003053815

ILMN_1691927

ILMN_2411264

PH_hs_0023794

TC15001764.hg

g13376847_3p_at

Participates

as a member of

BTB proteins [cytosol] (Homo sapiens)

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

btbd2a [cytosol] (Danio rerio)

Btbd1 [cytosol] (Mus musculus)

Btbd1 [cytosol] (Rattus norvegicus)

BTBD1 [cytosol] (Bos taurus)

BTBD1 [cytosol] (Canis familiaris)

BTBD1 [cytosol] (Dictyostelium discoideum)

BTBD1 [cytosol] (Gallus gallus)

BTBD1 [cytosol] (Sus scrofa)

tag-30 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001011885.1, NP_079514.1

OpenTargets

ENSG00000064726

HPA

ENSG00000064726-BTBD1

GeneCards

Q9H0C5

Ensembl

ENSG00000064726, ENST00000261721, ENSP00000261721, ENSP00000368713, ENST00000379403

PRO

Q9H0C5

Pharos - Targets

Q9H0C5

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.61	4
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.556	3
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.556	3
UniProt:O95926 SYF2	1	SYF2 [nucleoplasm] (R-HSA-8867884)	0.527	2
UniProt:Q9Y296 TRAPPC4	2	TRAPPC4 [plasma membrane] (R-HSA-2682314) TRAPPC4 [cytosol] (R-HSA-5683764)	0.527	2
UniProt:P61081 UBE2M	5	AcM-UBE2M [nucleoplasm] (R-HSA-8952502) G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) UBE2M [cytosol] (R-HSA-947619) AcM-UBE2M [cytosol] (R-HSA-8951627) G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894)	0.527	2
UniProt:Q9NZ63 C9orf78	1	C9orf78 [nucleoplasm] (R-HSA-9769588)	0.527	2
UniProt:P49674 CSNK1E	2	CSNK1E [nucleoplasm] (R-HSA-421306) CSNK1E [cytosol] (R-HSA-205877)	0.527	2
UniProt:Q8N4J0 CARNMT1	1	CARNMT1 [cytosol] (R-HSA-8876689)	0.527	2