Reactome | HACE1 [cytosol]

HACE1 [cytosol]

Stable Identifier

R-HSA-8851654

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase HACE1 ecNumber6.3.2.-/ecNumber, HACE1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8IYU2 HACE1

Gene Names

HACE1, KIAA1320

Chain

chain:1-909

Reference Genes

BioGPS Gene:57531 HACE1

COSMIC (genes):HACE1 HACE1

CTD Gene:57531 HACE1

dbSNP Gene:57531 HACE1

ENSEMBL:ENSG00000085382 HACE1

ENSEMBL_homo_sapiens_GENE:ENSG00000085382.12 HACE1

HGNC:21033 HACE1

KEGG Gene (Homo sapiens):57531 HACE1

Monarch:57531 HACE1

NCBI Gene:57531 HACE1

OMIM:610876 HACE1

UCSC:Q8IYU2 HACE1

Reference Transcript

Other Identifiers

11734158_a_at

11734159_a_at

11755557_a_at

17022097

227471_PM_at

227471_at

2967164

2967165

2967166

2967168

2967172

2967173

2967174

2967175

2967176

2967177

2967179

2967180

2967183

2967184

2967185

2967186

2967187

2967192

2967193

2967194

2967195

2967196

2967197

2967198

2967199

2967200

2967201

2967202

2967204

2967205

2967206

47428_r_at

57531

63130_at

8128522

A_23_P250002

A_33_P3420402

GE53902

GO:0000139

GO:0000209

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005794

GO:0006511

GO:0007030

GO:0007049

GO:0016020

GO:0016567

GO:0016601

GO:0016604

GO:0016740

GO:0023052

GO:0030163

GO:0030334

GO:0031267

GO:0032580

GO:0036211

GO:0043226

GO:0048870

GO:0061024

GO:0061025

GO:0061630

GO:0070936

GO:0140096

HMNXSV003032295

Hs.117414.0.S1_3p_at

ILMN_1740217

PH_hs_0023382

TC06001972.hg

Participates

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

ptr1 [cytosol] (Schizosaccharomyces pombe)

HUWE1 [cytosol] (Drosophila melanogaster)

HACE1 [cytosol] (Bos taurus)

HACE1 [cytosol] (Canis familiaris)

HACE1 [cytosol] (Dictyostelium discoideum)

HACE1 [cytosol] (Gallus gallus)

HACE1 [cytosol] (Plasmodium falciparum)

HACE1 [cytosol] (Sus scrofa)

Hace1 [cytosol] (Mus musculus)

Hace1 [cytosol] (Rattus norvegicus)

Homologues of HACE1 [cytosol] (Dictyostelium discoideum)

eel-1 [cytosol] (Caenorhabditis elegans)

TOM1 [cytosol] (Saccharomyces cerevisiae)

hace1 [cytosol] (Danio rerio)

hace1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_065822.2, NP_001308009.1, NP_001308013.1, NP_001308012.1

OpenTargets

ENSG00000085382

GeneCards

Q8IYU2

HPA

ENSG00000085382-HACE1

Ensembl

ENST00000369125, ENSP00000358121, ENSG00000085382, ENST00000262903, ENSP00000262903

PRO

Q8IYU2

Pharos - Targets

Q8IYU2

Orphanet

21554

PDB

8H8X, 8HAE

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CV9 OPTN	5	OPTN [recycling endosome membrane] (R-HSA-8854141) OPTN [Golgi membrane] (R-HSA-2161111) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [cytosol] (R-HSA-9687907)	0.693	15
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.619	5