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FGFR2 IIIa TM [extracellular region]
Stable Identifier
R-HSA-8851703
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR2 in disease (Homo sapiens)
FGFR2 mutant receptor activation (Homo sapiens)
Signaling by FGFR2 IIIa TM (Homo sapiens)
Aberrant alternative splicing yields a secreted FGFR2 IIIa TM disease variant (Homo sapiens)
FGFR2 IIIa TM [extracellular region] (Homo sapiens)
FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling (Homo sapiens)
FGFR2 IIIa TM [extracellular region] (Homo sapiens)
FGFR2IIIa TM:FGF1,2:FGFR2b, FGFR2c [plasma membrane] (Homo sapiens)
FGFR2 IIIa TM [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P21802 FGFR2
Gene Names
FGFR2, BEK, KGFR, KSAM
Chain
signal peptide:1-21, chain:22-821
Reference Genes
ENSEMBL:ENSG00000066468 FGFR2
Participates
as a component of
FGFR2IIIa TM:FGF1,2:FGFR2b, FGFR2c [plasma membrane] (Homo sapiens)
as an input of
FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling (Homo sapiens)
as an output of
Aberrant alternative splicing yields a secreted FGFR2 IIIa TM disease variant (Homo sapiens)
Other forms of this molecule
FGFR2 [plasma membrane]
FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane]
FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane]
FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane]
FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane]
FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane]
FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane]
FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane]
FGFR2 N549H [plasma membrane]
FGFR2 N549K [plasma membrane]
FGFR2 K660N [plasma membrane]
p-8Y-FGFR2 K660M [plasma membrane]
p-8Y-FGFR2 K660E [plasma membrane]
phosphorylated FGFR2 L764Hfs*4 [plasma membrane]
p-8Y-FGFR2 W290C [plasma membrane]
p-8Y-FGFR2 S267P [plasma membrane]
p-8Y-FGFR2 [plasma membrane]
p-8Y-FGFR2 N549K [plasma membrane]
p-8Y-FGFR2 N549H [plasma membrane]
p-8Y-FGFR2 K660N [plasma membrane]
p-6Y-FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane]
p-6Y-FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane]
p-6Y-FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane]
p-6Y-FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane]
p-6Y-FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane]
p-6Y-FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane]
p-6Y-FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane]
p-6Y-FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
FGFR2 W290C [plasma membrane]
FGFR2 L764Hfs*4 [plasma membrane]
FGFR2 S267P [plasma membrane]
FGFR2 K660E [plasma membrane]
FGFR2 K660M [plasma membrane]
Disease
Name
Identifier
Synonyms
acrocephalosyndactylia
DOID:12960
Apert syndrome
Interactors (30)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P09038 FGF2
1
FGF2(10-155) [extracellular region]
(R-HSA-189898)
0.779
5
UniProt:P51812 RPS6KA3
7
p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm]
(R-HSA-444286)
p-T365,S369,S386,T577,T737-RPS6KA3 [cytosol]
(R-HSA-9619989)
p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol]
(R-HSA-9619872)
p-T365,S369,T577-RPS6KA3 [cytosol]
(R-HSA-9619959)
RPS6KA3 [cytosol]
(R-HSA-444250)
p-4S,T231,T365-RPS6KA3 [nucleoplasm]
(R-HSA-199830)
RPS6KA3 [nucleoplasm]
(R-HSA-199869)
0.745
5
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.735
6
ChEBI:73280 SSR
0.683
8
UniProt:P05230 FGF1
1
FGF1 [extracellular region]
(R-HSA-189856)
0.675
3
UniProt:P11362 FGFR1
9
FGFR1 [plasma membrane]
(R-HSA-9756433)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
0.623
3
UniProt:O15520 FGF10
1
FGF10 [extracellular region]
(R-HSA-189869)
0.571
2
UniProt:P19174 PLCG1
6
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
0.528
3
UniProt:Q3MIR4 CC50B
0.527
2
UniProt:O60637 TSN3
0.527
2
UniProt:Q96LL9 DJC30
0.527
2
UniProt:Q6P047 CH074
0.527
2
UniProt:Q99732 LITAF
0.527
2
UniProt:Q8N7X8 SIGL1
0.527
2
UniProt:Q5T9A4 ATAD3B
3
ATAD3B [secretory granule membrane]
(R-HSA-6801313)
ATAD3B [plasma membrane]
(R-HSA-6806518)
ATAD3B [ficolin-1-rich granule membrane]
(R-HSA-6801277)
0.527
2
UniProt:Q96HB5 CC120
0.527
2
UniProt:Q8IWX8 CHERP
1
CHERP [nucleoplasm]
(R-HSA-8865901)
0.527
2
UniProt:Q92551 IP6K1
2
IP6K1 [cytosol]
(R-HSA-1604591)
IP6K1 [nucleoplasm]
(R-HSA-2023952)
0.527
2
UniProt:Q6P995 F171B
0.527
2
UniProt:P34741 SDC2
20
HS(4)-SDC2 [plasma membrane]
(R-HSA-2076683)
HS(6)-SDC2 [plasma membrane]
(R-HSA-2076661)
HS(2)-SDC2 [plasma membrane]
(R-HSA-2076644)
HS(1)-SDC2 [plasma membrane]
(R-HSA-2076643)
HS(3)-SDC2 [plasma membrane]
(R-HSA-2076631)
HS(5)-SDC2 [plasma membrane]
(R-HSA-2076665)
SDC2 [endoplasmic reticulum lumen]
(R-HSA-8956741)
p-SDC2 [endoplasmic reticulum lumen]
(R-HSA-8956945)
XylS-SDC2 [Golgi lumen]
(R-HSA-2064109)
Gal-Xyl-SDC2 [Golgi lumen]
(R-HSA-2064132)
SDC2 [Golgi lumen]
(R-HSA-2054101)
Gal-Gal-Xyl-SDC2 [Golgi lumen]
(R-HSA-2063988)
GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen]
(R-HSA-2063997)
HS(3)-SDC2 [Golgi lumen]
(R-HSA-2076443)
HS(4)-SDC2 [Golgi lumen]
(R-HSA-2076356)
HS(2)-SDC2 [Golgi lumen]
(R-HSA-2076603)
HS(1)-SDC2 [Golgi lumen]
(R-HSA-2076607)
Heparan(4)-SDC2 [Golgi lumen]
(R-HSA-2076576)
Heparan(3)-SDC2 [Golgi lumen]
(R-HSA-2076361)
Heparan(2)-SDC2 [Golgi lumen]
(R-HSA-2076397)
0.527
2
UniProt:Q92575 UBXN4
0.527
2
UniProt:Q96L94 SNX22
0.527
2
UniProt:P01033 TIMP1
4
TIMP1 [platelet alpha granule lumen]
(R-HSA-349745)
p-TIMP1 [endoplasmic reticulum lumen]
(R-HSA-8957082)
TIMP1 [endoplasmic reticulum lumen]
(R-HSA-8956691)
TIMP1 [extracellular region]
(R-HSA-349743)
0.527
2
UniProt:Q96G30 MRAP2
0.527
2
UniProt:P55899 FCGRN
0.527
2
UniProt:Q5TF58 IFFO2
0.527
2
UniProt:Q06124 PTPN11
4
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
PTPN11 [cytosol]
(R-HSA-162563)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
0.519
2
UniProt:Q9ULH0 KIDINS220
2
p-Y1095-KIDINS220 [cytosol]
(R-HSA-169869)
KIDINS220 [cytosol]
(R-HSA-169880)
0.483
2
UniProt:Q9UBH6 S53A1
0.483
2
UniProt:Q86VI4 LAP4B
0.463
2
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