RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1

Stable Identifier
Reaction [transition]
Homo sapiens
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GRB2-1 is an adaptor protein for the RAS guanyl nucleotide exchange factor SOS1. GRB2-1, through association with activated receptor tyrosine kinases, such as MET, mediates recruitment of SOS1 to the plasma membrane. At the plasma membrane, SOS1 catalyzes guanyl nucleotide exchange on RAS proteins from GDP to GTP, resulting in RAS activation downstream of MET (Shen and Novak 1997, Besser et al. 1997).

Literature References
PubMed ID Title Journal Year
9070211 DDT stimulates c-erbB2, c-met, and STATS tyrosine phosphorylation, Grb2-Sos association, MAPK phosphorylation, and proliferation of human breast epithelial cells

Shen, K, Novak, RF

Biochem. Biophys. Res. Commun. 1997
9038378 Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2

Bardelli, A, Comoglio, PM, Besser, D, Thelen, M, Nagamine, Y, Ponzetto, C, Didichenko, S

Oncogene 1997
Catalyst Activity

guanyl-nucleotide exchange factor activity of HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane]

Orthologous Events
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