Activated MET binds RANBP9 and SOS1

Stable Identifier
R-HSA-8851859
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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RANBP9 binds to activated MET receptor and recruits RAS guanyl nucleotide exchange factor SOS1. RANBP9 can associate with unphosphorylated MET, but has a higher affinity for the activated receptor. The interaction involves the sprouty (SPRY) domain of RANBP9 and the tyrosine kinase domain of MET (Wang et al. 2002). RANBP9 competes with RANBP10 for MET binding. RANBP10 does not interact with SOS1, and RANBP10 binding inhibits activation of RAS downstream of MET (Wang et al. 2004).

Literature References
PubMed ID Title Journal Year
12147692 Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM

Wang, D, Li, Z, Messing, EM, Wu, G

J. Biol. Chem. 2002
14684163 A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling

Wang, D, Li, Z, Schoen, SR, Messing, EM, Wu, G

Biochem. Biophys. Res. Commun. 2004
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