MET phosphorylates SHC1-2

Stable Identifier
R-HSA-8851890
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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MET phosphorylates SHC1-2
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Activated MET receptor phosphorylates the splicing isoform 2 of the adapter protein SHC1 (SHC1-2) on tyrosine residue Y317 (Pelicci et al. 1995).
Literature References
PubMed ID Title Journal Year
7731718 The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein

Bardelli, A, Zhen, Z, Waterfield, MD, Lanfrancone, L, Salcini, AE, Ponzetto, C, Giordano, S, Pelicci, G, Pelicci, PG, Panayotou, G

Oncogene 1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of HGF:p-4Y-MET dimer:SHC1-2 [plasma membrane]

Physical Entity
HGF:p-4Y-MET dimer:SHC1-2 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
MET phosphorylates SHC1-2 (Bos taurus)
MET phosphorylates SHC1-2 (Canis familiaris)
MET phosphorylates SHC1-2 (Gallus gallus)
MET phosphorylates SHC1-2 (Mus musculus)
MET phosphorylates SHC1-2 (Rattus norvegicus)
MET phosphorylates SHC1-2 (Sus scrofa)
MET phosphorylates SHC1-2 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-06-14)
Reviewed
Birchmeier, W  (2016-07-11)
Heynen, G  (2016-07-11)
Created
Orlic-Milacic, M  (2016-01-12)
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