RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET

Stable Identifier
R-HSA-8851899
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SOS1, recruited to activated MET receptor via interaction of GRB2 with phosphorylated SHC1-2, catalyzes guanyl nucleotide exchange on RAS from GDP to GTP, resulting in RAS activation (Pelicci et al. 1995).

Literature References
PubMed ID Title Journal Year
7731718 The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein

Pelicci, G, Giordano, S, Zhen, Z, Salcini, AE, Lanfrancone, L, Bardelli, A, Panayotou, G, Waterfield, MD, Ponzetto, C, Pelicci, PG

Oncogene 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created