SHC1-2 bound to MET recruits GRB2:SOS1

Stable Identifier
R-HSA-8851900
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SHC1 splicing isoform 2 (SHC1-2) phosphorylated by MET on tyrosine residue Y317 recruits the GRB2:SOS1 complex to the activated MET receptor (Pelicci et al. 1995).

Literature References
PubMed ID Title Journal Year
7731718 The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein

Pelicci, G, Giordano, S, Zhen, Z, Salcini, AE, Lanfrancone, L, Bardelli, A, Panayotou, G, Waterfield, MD, Ponzetto, C, Pelicci, PG

Oncogene 1995
Participants
Participant Of
Orthologous Events
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Reviewed
Created