Reactome | MET activates PI3K/AKT signaling

MET activates PI3K/AKT signaling

Stable Identifier

R-HSA-8851907

Type

Pathway

Species

Homo sapiens

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MET binds and phosphorylates the adapter protein GAB1, thus creating a docking site for the regulatory subunit PIK3R1 of the PI3K complex. Recruitment of PI3K to MET-bound phosphorylated GAB1 results in PI3K activation, production of PIP3, and stimulation of downstream AKT signaling (Rodrigues et al. 2000, Schaeper et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10648629	A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling Rodrigues, GA, Falasca, M, Zhang, Z, Ong, SH, Schlessinger, J	Mol Cell Biol	2000
10871282	Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses Schaeper, U, Gehring, NH, Fuchs, KP, Sachs, M, Kempkes, B, Birchmeier, W	J. Cell Biol.	2000