Reactome: A Curated Pathway Database

MET activates PI3K/AKT signaling

Stable Identifier
R-HSA-8851907
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

MET binds and phosphorylates the adapter protein GAB1, thus creating a docking site for the regulatory subunit PIK3R1 of the PI3K complex. Recruitment of PI3K to MET-bound phosphorylated GAB1 results in PI3K activation, production of PIP3, and stimulation of downstream AKT signaling (Rodrigues et al. 2000, Schaeper et al. 2000).

Literature References
Participants
Participant Of
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Orthologous Events
Cross References