MET binds and phosphorylates the adapter protein GAB1, thus creating a docking site for the regulatory subunit PIK3R1 of the PI3K complex. Recruitment of PI3K to MET-bound phosphorylated GAB1 results in PI3K activation, production of PIP3, and stimulation of downstream AKT signaling (Rodrigues et al. 2000, Schaeper et al. 2000).
Rodrigues, GA, Falasca, M, Zhang, Z, Ong, SH, Schlessinger, J
Schaeper, U, Gehring, NH, Fuchs, KP, Sachs, M, Kempkes, B, Birchmeier, W
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