Reactome | MET activates PI3K/AKT signaling

MET activates PI3K/AKT signaling

Stable Identifier

R-HSA-8851907

Type

Pathway

Species

Homo sapiens

Locations in the PathwayBrowser

Expand all

Summation

MET binds and phosphorylates the adapter protein GAB1, thus creating a docking site for the regulatory subunit PIK3R1 of the PI3K complex. Recruitment of PI3K to MET-bound phosphorylated GAB1 results in PI3K activation, production of PIP3, and stimulation of downstream AKT signaling (Rodrigues et al. 2000, Schaeper et al. 2000).

Literature References

10648629	A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling	Mol Cell Biol	2000
10871282	Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses	J. Cell Biol.	2000

Participants

events

Activated MET binds GAB1 (Homo sapiens)
Activated MET binds GAB1 and GRB2 (Homo sapiens)
MET phosphorylates GAB1 (Homo sapiens)
Phosphorylated GAB1 recruits PI3K to MET (Homo sapiens)
MET bound PI3K generates PIP3 (Homo sapiens)

Participant Of

hasEvent

Signaling by MET

Orthologous Events

MET activates PI3K/AKT signaling (Bos taurus)
MET activates PI3K/AKT signaling (Caenorhabditis elegans)
MET activates PI3K/AKT signaling (Canis familiaris)
MET activates PI3K/AKT signaling (Danio rerio)
MET activates PI3K/AKT signaling (Drosophila melanogaster)
MET activates PI3K/AKT signaling (Gallus gallus)
MET activates PI3K/AKT signaling (Mus musculus)
MET activates PI3K/AKT signaling (Rattus norvegicus)
MET activates PI3K/AKT signaling (Sus scrofa)
MET activates PI3K/AKT signaling (Taeniopygia guttata)
MET activates PI3K/AKT signaling (Xenopus tropicalis)

Cross References

BioModels Database

BIOMD0000000468, BIOMD0000000594, BIOMD0000000255, BIOMD0000000424, BIOMD0000000477, BIOMD0000000175