BTNL2 binds activated T cells surface

Stable Identifier
R-HSA-8852010
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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BTNL2 binds activated T cells surface
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Butyrophilin-like 2 (BTNL2), is a butyrophilin family member with homology to the B7 costimulatory molecules. BTNL2 binds to a putative receptor on activated T cells and functions to have an inhibitory effect on CD4+ T cell proliferation (Nguyen et al. 2006). It may also bind to receptors on liver and vascular endothelium in mouse (Arnett et al. 2007). Polymorphisms in BTNL2 have been linked with various autoimmune and inflammatory diseases (Pathan et al. 2009, Mochida et al. 2009, Arnett & Viney 2014).
Literature References
PubMed ID Title Journal Year
16751379 BTNL2, a butyrophilin-like molecule that functions to inhibit T cell activation

Dong, C, Nguyen, T, Zhang, Y, Liu, XK

J. Immunol. 2006
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Authored
Garapati, P V  (2016-01-05)
Reviewed
Reith, W  (2016-09-09)
Rhodes, DA  (2017-03-01)
Created
Garapati, P V  (2016-01-12)
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