UBA1 adenylates ubiquitin in the nucleoplasm

Stable Identifier
R-HSA-8852128
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

UBA1 is present in both the cytosol and nucleoplasm (Grenfell et al. 1994). Activation of ubiquitin by UBA1 proceeds through 3 steps: adenylation of ubiquitin, conjugation of ubiquitin from adenyl-ubiquitin to an internal cysteine residue of UBA1, and adenylation of a second molecule of ubiquitin. In the first step, the adenylation module of UBA1 catalyzes the acyl-adenylation of the C-terminal glycine of ubiquitin (Jin et al. 2007, inferred from the rabbit homologue in Haas et al. 1982, Hershko et al. 1983, reviewed in Groettrup et al. 2008).

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