Reactome | GRK6 [plasma membrane]

GRK6 [plasma membrane]

Stable Identifier

R-HSA-8852159

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G protein-coupled receptor kinase 6 ecNumber2.7.11.16/ecNumber, GRK6_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P43250 GRK6

Gene Names

GRK6, GPRK6

Chain

chain:1-576

Reference Genes

BioGPS Gene:2870 GRK6

COSMIC (genes):GRK6 GRK6

CTD Gene:2870 GRK6

dbSNP Gene:2870 GRK6

ENSEMBL:ENSG00000198055 GRK6

ENSEMBL_homo_sapiens_GENE:ENSG00000198055.11 GRK6

HGNC:4545 GRK6

KEGG Gene (Homo sapiens):2870 GRK6

Monarch:2870 GRK6

NCBI Gene:2870 GRK6

OMIM:600869 GRK6

UCSC:P43250 GRK6

Reference Transcript

Other Identifiers

11733845_at

11733846_a_at

11738256_a_at

11738257_x_at

1392_at

16993088

202848_PM_s_at

202848_s_at

202849_PM_x_at

202849_x_at

210981_PM_s_at

210981_s_at

211543_PM_s_at

211543_s_at

2843170

2843171

2843172

2843177

2843179

2843180

2843181

2843182

2843183

2843184

2843185

2843186

2843187

2843188

2843190

2843194

2843195

2843197

2843198

2843200

2843201

2843202

2843203

2843204

2843205

2870

3480780

3480794

3480798

8110362

A_23_P257256

A_33_P3264875

GE57652

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004703

GO:0005515

GO:0005524

GO:0005737

GO:0005886

GO:0006468

GO:0007165

GO:0007186

GO:0008277

GO:0009966

GO:0016020

GO:0016055

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0036211

GO:0047696

GO:0140096

HMNXSV003039250

Hs.76297.0.A1_3p_a_at

ILMN_1681802

ILMN_2357015

L16862_at

PH_hs_0032251

TC05001015.hg

g3005015_3p_a_at

g4504100_3p_x_at

Participates

as a member of

GRK2, GRK3, GRK5, GRK6 [plasma membrane] (Homo sapiens)

Inferred To

GRK6 [plasma membrane] (Bos taurus)

GRK6 [plasma membrane] (Canis familiaris)

GRK6 [plasma membrane] (Drosophila melanogaster)

GRK6 [plasma membrane] (Gallus gallus)

GRK6 [plasma membrane] (Mus musculus)

GRK6 [plasma membrane] (Rattus norvegicus)

GRK6 [plasma membrane] (Sus scrofa)

GRK6 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001004105.1, NP_002073.2, NP_001004106.1

Guide to Pharmacology - Targets

1470

OpenTargets

ENSG00000198055

ZINC - Substances

GRK6_HUMAN

ZINC - Biogenic

GRK6_HUMAN

ZINC target

P43250

PRO

P43250

PDB

3NYN, 2ACX, 3NYO

IntEnz

2.7.11.16

HPA

ENSG00000198055-GRK6

GeneCards

P43250

Ensembl

ENSP00000348230, ENSG00000198055, ENSP00000347655, ENST00000355958, ENST00000528793, ENSP00000433511, ENST00000355472

Pharos - Targets

P43250

ZINC - Predictions - Purchasable

GRK6_HUMAN

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	2
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3

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