Inactivation of LCK by PTPN22

Stable Identifier
R-HSA-8852200
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Inactivation of LCK by LYP
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Protein tyrosine phosphatase PTPN22 (LYP, PEP) (Cohen et al. 1999) dephosphorylates tyrosine residue Y394 of LCK, thus inactivating LCK and down-regulating TCR signaling (Wu et al. 2006, Vang et al. 2012).

Literature References
PubMed ID Title Journal Year
16461343 Identification of substrates of human protein-tyrosine phosphatase PTPN22

Wu, J, Katrekar, A, Honigberg, LA, Smith, AM, Conn, MT, Tang, J, Jeffery, D, Mortara, K, Sampang, J, Williams, SR, Buggy, J, Clark, JM

J. Biol. Chem. 2006
22426112 LYP inhibits T-cell activation when dissociated from CSK

Vang, T, Liu, WH, Delacroix, L, Wu, S, Vasile, S, Dahl, R, Yang, L, Musumeci, L, Francis, D, Landskron, J, Tasken, K, Tremblay, ML, Lie, BA, Page, R, Mustelin, T, Rahmouni, S, Rickert, RC, Tautz, L

Nat. Chem. Biol. 2012
Participants
Participates
Catalyst Activity

protein tyrosine phosphatase activity of PTPN22 [cytosol]

Orthologous Events
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