Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends

Stable Identifier
R-HSA-8852306
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Starting in mitotic prometaphase, GTSE1 becomes phosphorylated at threonine residues T513 and T526 (and possibly other sites), located adjacent to the two SKIP-like motifs involved in binding to MAPRE1 (EB1). Mitotic phosphorylation of GTSE1 inhibits its association with microtubule plus ends. CDK1 activity inhibits the association of recombinant human GTSE1 with microtubule plus ends in Xenopus extracts, but it is not certain whether CDK1 or another mitotic kinase phosphorylates GTSE1 (Scolz et al. 2012).

Literature References
PubMed ID Title Journal Year
23236459 GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration

Scolz, M, Widlund, PO, Piazza, S, Bublik, DR, Reber, S, Peche, LY, Ciani, Y, Hubner, N, Isokane, M, Monte, M, Ellenberg, J, Hyman, AA, Schneider, C, Bird, AW

PLoS ONE 2012
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Mitotic kinase [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created