PLK1 phosphorylates GTSE1

Stable Identifier
R-HSA-8852317
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated PLK1 phosphorylates GTSE1 on serine residue S435, located in immediate vicinity of the GTSE1 nuclear localization signal (NLS) R431RR433 (Arg431Arg432Arg433). PLK1-mediated phosphorylation promotes GTSE1 nuclear translocation, possibly by exposing the NLS of GTSE1 to the nuclear import machinery. PLK1 can also phosphorylate human GTSE1 on serine residue S233. S233 is not evolutionarily conserved and is therefore not shown (Liu et al. 2010).

Literature References
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Event Information
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of GTSE1:p-T210-PLK1 [cytosol]
Physical Entity
Activity
Orthologous Events
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