GTSE1 translocates to the nucleus

Stable Identifier
R-HSA-8852331
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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PLK1-mediated phosphorylation of GTSE1 is needed for nuclear accumulation of GTSE1, probably because it exposes the nuclear localization signal (NLS) of GTSE1 to the nuclear import machinery. Nuclear localization of GTSE1 is not needed for normal G2 phase progression, but is needed for the G2 checkpoint recovery (cell cycle re-entry after G2 checkpoint arrest) (Liu et al. 2010).

Literature References
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created