Reactome | p-S435-GTSE1 [nucleoplasm]

p-S435-GTSE1 [nucleoplasm]

Stable Identifier

R-HSA-8852332

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser for interactor UniProt:O95630 STAMBP

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External Reference Information

External Reference

UniProt:Q9NYZ3 GTSE1

Gene Names

GTSE1

Chain

chain:1-739

Reference Genes

BioGPS Gene:51512 GTSE1

COSMIC (genes):GTSE1 GTSE1

CTD Gene:51512 GTSE1

dbSNP Gene:51512 GTSE1

ENSEMBL:ENSG00000075218 GTSE1

ENSEMBL_homo_sapiens_GENE:ENSG00000075218.19 GTSE1

HGNC:13698 GTSE1

KEGG Gene (Homo sapiens):51512 GTSE1

Monarch:51512 GTSE1

NCBI Gene:51512 GTSE1

OMIM:607477 GTSE1

UCSC:Q9NYZ3 GTSE1

Reference Transcript

Other Identifiers

11736082_a_at

11736083_x_at

16931384

204315_PM_s_at

204315_s_at

204318_PM_s_at

204318_s_at

211040_PM_x_at

211040_x_at

215942_PM_s_at

215942_s_at

39374_at

39375_g_at

3949056

3949059

3949061

3949062

3949063

3949064

3949067

3949068

3949070

3949078

3949080

3949082

3949083

3949085

3949087

3949088

3949089

3949090

3949091

39872_at

51512

63703_s_at

8073858

A_14_P135311

A_23_P57588

GE82125

GO:0000278

GO:0003674

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005874

GO:0005881

GO:0006977

GO:0007017

GO:0008017

GO:0008092

GO:0015630

GO:0016020

GO:0023052

GO:0043226

HMNXSV003027674

Hs.122552.0.S1_3p_s_at

Hs.122552.2.S1_3p_s_at

TC22000394.hg

g13623450_3p_s_at

p33936

Participates

as an output of

GTSE1 translocates to the nucleus (Homo sapiens)

as an input of

GTSE1 binds TP53 (Homo sapiens)

as a component of

p-S435-GTSE1:PolyUb-TP53 Tetramer [nucleoplasm] (Homo sapiens)

Other forms of this molecule

GTSE1 [cytosol]

p-S435-GTSE1 [cytosol]

p-T513,T526-GTSE1 [cytosol]

Inferred To

phospho-p-S435-GTSE1 [nucleoplasm] (Gallus gallus)

phospho-GTSE1 [nucleoplasm] (Bos taurus)

phospho-GTSE1 [nucleoplasm] (Canis familiaris)

phospho-GTSE1 [nucleoplasm] (Sus scrofa)

phospho-gtse1 [nucleoplasm] (Danio rerio)

phospho-gtse1 [nucleoplasm] (Xenopus tropicalis)

phospho-Gtse1 [nucleoplasm] (Mus musculus)

phospho-Gtse1 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-serine at 435

Coordinate

435

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_016884304.1, NP_057510.4, XP_005261684.1

OpenTargets

ENSG00000075218

GeneCards

Q9NYZ3

HPA

ENSG00000075218-GTSE1

Ensembl

ENSG00000075218, ENST00000454366, ENSP00000415430

PRO

Q9NYZ3

Pharos - Targets

Q9NYZ3

PDB

6QNN, 6QNP

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q709F0 ACAD11	1	ACAD11 [mitochondrial inner membrane] (R-HSA-5695987)	0.643	3
UniProt:Q96FJ0 STAMBPL1	1	STAMBPL1 [cytosol] (R-HSA-6783264)	0.643	3
UniProt:O95630 STAMBP	1	STAMBP [cytosol] (R-HSA-5693063)	0.643	3
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.571	6
UniProt:Q00610 CLTC	10	CLTC [trans-Golgi network membrane] (R-HSA-5333703) CLTC [cytosol] (R-HSA-8856820) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol] (R-HSA-9710852) CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710854) CLTC [plasma membrane] (R-HSA-2980668) CLTC [lysosomal membrane] (R-HSA-2980660) CLTC [clathrin-coated endocytic vesicle membrane] (R-HSA-5138450) CLTC [endolysosome membrane] (R-HSA-8870827) CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol] (R-HSA-9710853) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9710835)	0.564	3
UniProt:Q9UJY5 GGA1	2	GGA1 [early endosome membrane] (R-HSA-8854136) GGA1 [endosome membrane] (R-HSA-5692930)	0.544	2
UniProt:Q01968 OCRL	4	OCRL [Golgi membrane] (R-HSA-434339) OCRL [cytoplasmic vesicle membrane] (R-HSA-434214) OCRL [plasma membrane] (R-HSA-3769049) OCRL [cytosol] (R-HSA-1806196)	0.527	2
UniProt:Q13492 PICALM	3	PICALM [cytosol] (R-HSA-8867593) PICALM [cytoplasmic vesicle membrane] (R-HSA-429812) PICALM [Golgi membrane] (R-HSA-434341)	0.527	2
UniProt:Q5SZD1 CF141			0.527	2
UniProt:Q06190 P2R3A			0.527	2
UniProt:P01350 GAST	1	GAST(76-92) [extracellular region] (R-HSA-870266)	0.527	2
UniProt:Q92466 DDB2	3	PolyUb-DDB2 [nucleoplasm] (R-HSA-6783035) DDB2 [nucleoplasm] (R-HSA-53491) PAR-DDB2 [nucleoplasm] (R-HSA-5696654)	0.527	2
UniProt:P56539 CAV3	1	CAV3 [plasma membrane] (R-HSA-1368135)	0.527	2
UniProt:Q8WTP9 XAGE3			0.527	2
UniProt:Q13492-2 PICALM			0.527	2
UniProt:Q9Y664 KPTN	1	KPTN [lysosomal membrane] (R-HSA-9638238)	0.527	2

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