GTSE1 binds TP53

Stable Identifier
R-HSA-8852337
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Since MDM2-mediated ubiquitination of TP53 promotes translocation of TP53 to the cytosol, and since GTSE1-facilitated translocation of TP53 to the cytosol depends on the functional MDM2 (with no reported interaction between GTSE1 and MDM2) (Monte et al. 2004), it is plausible that GTSE1 binds to TP53 polyubiquitinated by MDM2. The interaction between TP53 and GTSE1 involves the C-terminal regulatory domain of TP53 and the C-terminus of GTSE1 (Monte et al. 2003).

Literature References
PubMed ID Title Journal Year
14707141 hGTSE-1 expression stimulates cytoplasmic localization of p53

Monte, M, Benetti, R, Collavin, L, Marchionni, L, Del Sal, G, Schneider, C

J. Biol. Chem. 2004
12750368 The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function

Monte, M, Benetti, R, Buscemi, G, Sandy, P, Del Sal, G, Schneider, C

J. Biol. Chem. 2003
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