GTSE1 facilitates proteasome-mediated degradation of TP53

Stable Identifier
R-HSA-8852354
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

GTSE1 promotes down-regulation of TP53 in a proteasome-dependent way. Nuclear export of TP53 facilitated by GTSE1 and MDM2likely makes ubiquitinated TP53 available to the proteasome machinery. GTSE1-mediated decrease of TP53 levels is needed for the G2 checkpoint recovery (cell cycle re-entry after DNA damage induced G2 arrest) and rescues cells from DNA damage induced apoptosis during S/G2 phase (Monte et al. 2003, Monte et al. 2004).

Literature References
PubMed ID Title Journal Year
14707141 hGTSE-1 expression stimulates cytoplasmic localization of p53

Monte, M, Benetti, R, Collavin, L, Marchionni, L, Del Sal, G, Schneider, C

J. Biol. Chem. 2004
12750368 The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function

Monte, M, Benetti, R, Buscemi, G, Sandy, P, Del Sal, G, Schneider, C

J. Biol. Chem. 2003
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed