GTSE1 binds CDKN1A

Stable Identifier
R-HSA-8852362
Type
Reaction [binding]
Species
Homo sapiens
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Stabilization of the newly synthesized protein product of the CDKN1A (p21) gene, a CDK inhibitor and a TP53 (p53) transcriptional target, requires binding of CDKN1A to FKBPL (WISp39). FKBPL simultaneously interacts with CDKN1A and a chaperone protein HSP90, forming a ternary complex (Jascur et al. 2005). GTSE1 was identified as another component of the complex of CDKN1A, FKBPL and HSP90. GTSE1 directly interacts with CDKN1A and FKBPL and contributes to CDKN1A stabilization (Bublik et al. 2010). Increased CDKN1A levels delay G2/M onset and rescue cells from G2 checkpoint-induced apoptosis, thus causing resistance to taxol induced cytotoxicity (Yu et al. 1998, Bublik et al. 2010).

Literature References
PubMed ID Title Journal Year
20018861 Human GTSE-1 regulates p21(CIP1/WAF1) stability conferring resistance to paclitaxel treatment

Bublik, DR, Scolz, M, Triolo, G, Monte, M, Schneider, C

J. Biol. Chem. 2010
15664193 Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein

Jascur, T, Brickner, H, Salles-Passador, I, Barbier, V, El Khissiin, A, Smith, B, Fotedar, R, Fotedar, A

Mol. Cell 2005
9844631 Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase

Yu, D, Jing, T, Liu, B, Yao, J, Tan, M, McDonnell, TJ, Hung, MC

Mol. Cell 1998
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