Reactome | MST1R autophosphorylates

MST1R autophosphorylates

Stable Identifier

R-HSA-8852552

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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In response to ligand binding and receptor dimerisation, macrophage-stimulating protein receptor (MST1R aka RON) autophosphorylates on Tyr-1238 and Tyr-1239 in the kinase domain. This leads to further phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site (Yokoyama et al. 2005, Wang et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
15632155	The C terminus of RON tyrosine kinase plays an autoinhibitory role Hayman, MJ, Ischenko, I, Miller, WT, Yokoyama, N	J. Biol. Chem.	2005
20726546	The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis Wang, J, Schreiner, P, Augustin, M, Steinbacher, S, Epstein, D, Mulvihill, MJ, Crew, AP	Biochemistry	2010