Signaling by FGFR2 fusions

Stable Identifier
R-HSA-8853333
Type
Pathway
Species
Homo sapiens
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FGFR2 fusions have been identified in cancers such as lung, breast, thyroid and cholangiocarcinoma (Wu et al, 2013; Seo et al, 2012; Arai et al, 2013). Of all the FGF receptors, FGFR2 shows the broadest range of 3' fusion partners, including BICC1, AHCYL1, CIT, CCDC6, CASP7, AFF3, OFD1 and CCAR2. Many of these fusion partners contain dimerization domains, suggesting that the resulting fusions may demonstrate constitutive ligand-independent activation (Wu et al, 2013; Arai et al, 2013; Seo et al, 2012; reviewed in Parker et al, 2014).

Literature References
PubMed ID Title Journal Year
23558953 Identification of targetable FGFR gene fusions in diverse cancers

Wu, YM, Su, F, Kalyana-Sundaram, S, Khazanov, N, Ateeq, B, Cao, X, Lonigro, RJ, Vats, P, Wang, R, Lin, SF, Cheng, AJ, Kunju, LP, Siddiqui, J, Tomlins, SA, Wyngaard, P, Sadis, S, Roychowdhury, S, Hussain, MH, Feng, FY, Zalupski, MM, Talpaz, M, Pienta, KJ, Rhodes, DR, Robinson, DR, Chinnaiyan, AM

Cancer Discov 2013
22975805 The transcriptional landscape and mutational profile of lung adenocarcinoma

Seo, JS, Ju, YS, Lee, WC, Shin, JY, Lee, JK, Bleazard, T, Lee, J, Jung, YJ, Kim, JO, Shin, JY, Yu, SB, Kim, J, Lee, ER, Kang, CH, Park, IK, Rhee, H, Lee, SH, Kim, JI, Kang, JH, Kim, YT

Genome Res. 2012
24122810 Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma

Arai, Y, Totoki, Y, Hosoda, F, Shirota, T, Hama, N, Nakamura, H, Ojima, H, Furuta, K, Shimada, K, Okusaka, T, Kosuge, T, Shibata, T

Hepatology 2014
24588013 Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours

Parker, BC, Engels, M, Annala, M, Zhang, W

J. Pathol. 2014
Participants
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Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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