Reactome: A Curated Pathway Database

Signaling by FGFR2 fusions

Stable Identifier
R-HSA-8853333
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

FGFR2 fusions have been identified in cancers such as lung, breast, thyroid and cholangiocarcinoma (Wu et al, 2013; Seo et al, 2012; Arai et al, 2013). Of all the FGF receptors, FGFR2 shows the broadest range of 3' fusion partners, including BICC1, AHCYL1, CIT, CCDC6, CASP7, AFF3, OFD1 and CCAR2. Many of these fusion partners contain dimerization domains, suggesting that the resulting fusions may demonstrate constitutive ligand-independent activation (Wu et al, 2013; Arai et al, 2013; Seo et al, 2012; reviewed in Parker et al, 2014).

Literature References
Participants
Participant Of
Disease
Diseases
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer