Signaling by plasma membrane FGFR1 fusions

Stable Identifier
R-HSA-8853336
Type
Pathway
Species
Homo sapiens
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In addition to the cytosolic FGFR1 fusions identified in 8 myeloproliferative syndrome, plasma membrane localized FGFR1 fusions have been identified in glioblastoma, breast cancer and non small cell lung cancers (Singh et al, 2012; Wu et al, 2013; Wang et al, 2014). A FGFR1:TACC1 fusion identified in glioblastoma promotes anchorage independent growth when expressed in Rat1A cells, while an ERLIN2:FGFR1 fusion in breast cancer shows constitutive autophosphorylation when expressed in HEK 293 cells (Singh et al, 2012; Wu et al, 2013). All FGFR1 fusions tested also shown increased sensitivity to growth inhibition upon treatment with kinase inhibitors (Singh et al, 2012; Wu et al, 2013; Wang et al, 2014; reviewed in Parker et al, 2014).

Literature References
PubMed ID Title Journal Year
22837387 Transforming fusions of FGFR and TACC genes in human glioblastoma

Singh, D, Chan, JM, Zoppoli, P, Niola, F, Sullivan, R, Castano, A, Liu, EM, Reichel, J, Porrati, P, Pellegatta, S, Qiu, K, Gao, Z, Ceccarelli, M, Riccardi, R, Brat, DJ, Guha, A, Aldape, K, Golfinos, JG, Zagzag, D, Mikkelsen, T, Finocchiaro, G, Lasorella, A, Rabadan, R, Iavarone, A

Science 2012
23558953 Identification of targetable FGFR gene fusions in diverse cancers

Wu, YM, Su, F, Kalyana-Sundaram, S, Khazanov, N, Ateeq, B, Cao, X, Lonigro, RJ, Vats, P, Wang, R, Lin, SF, Cheng, AJ, Kunju, LP, Siddiqui, J, Tomlins, SA, Wyngaard, P, Sadis, S, Roychowdhury, S, Hussain, MH, Feng, FY, Zalupski, MM, Talpaz, M, Pienta, KJ, Rhodes, DR, Robinson, DR, Chinnaiyan, AM

Cancer Discov 2013
24850843 FGFR1/3 tyrosine kinase fusions define a unique molecular subtype of non-small cell lung cancer

Wang, R, Wang, L, Li, Y, Hu, H, Shen, L, Shen, X, Pan, Y, Ye, T, Zhang, Y, Luo, X, Zhang, Y, Pan, B, Li, B, Li, H, Zhang, J, Pao, W, Ji, H, Sun, Y, Chen, H

Clin. Cancer Res. 2014
24588013 Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours

Parker, BC, Engels, M, Annala, M, Zhang, W

J. Pathol. 2014
Participants
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created