ENGASE hydrolyses unfolded protein:(GlcNAc)2 (Man(9-5)

Stable Identifier
R-HSA-8853379
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Two cytosolic deglycosylating systems can generate free oligosaccharides from glycoproteins; a deglycosylation complex that hydrolyses the whole glycan from an unfolded protein and cytosolic endo-beta-N-acetylglucosaminidase (ENGASE) that catalyses the endohydrolysis of -(Man(GlcNAc)2)Asn- structures in glycoproteins, leaving one N-acetyl-D-glucosamine (GlcNAc) residue attached to the protein (Suzuki et al. 2002). Glycans with a single GlcNAc at their reducing termini need to be further degraded by a cytosolic alpha-mannosidase, MAN2C1.

Literature References
PubMed ID Title Journal Year
12114544 Endo-beta-N-acetylglucosaminidase, an enzyme involved in processing of free oligosaccharides in the cytosol

Suzuki, T, Yano, K, Sugimoto, S, Kitajima, K, Lennarz, WJ, Inoue, S, Inoue, Y, Emori, Y

Proc. Natl. Acad. Sci. U.S.A. 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity of ENGASE [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created