PHLDA1 binds AURKA

Stable Identifier
R-HSA-8853429
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Aurora kinase A binds PHLDA1 (TDAG51) and the two proteins co-localize in the cytosol (Johnson et al. 2011). Although phosphorylation of AURKA at threonine residue T288 within the catalytic loop of AURKA is needed for AURKA kinase activity (Walter et al. 2000), AURKA phosphorylation has not been specifically examined in the context of AURKA interaction with PHLDA1 and AURKA is therefore shown as unphosphorylated.

Literature References
PubMed ID Title Journal Year
21807936 PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer

Johnson, EO, Chang, KH, de Pablo, Y, Ghosh, S, Mehta, R, Badve, S, Shah, K

J. Cell. Sci. 2011
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