PHLDA1 binds AURKA

Stable Identifier
R-HSA-8853429
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PHLDA1 binds AURKA
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Aurora kinase A binds PHLDA1 (TDAG51) and the two proteins co-localize in the cytosol (Johnson et al. 2011). Although phosphorylation of AURKA at threonine residue T288 within the catalytic loop of AURKA is needed for AURKA kinase activity (Walter et al. 2000), AURKA phosphorylation has not been specifically examined in the context of AURKA interaction with PHLDA1 and AURKA is therefore shown as unphosphorylated.
Literature References
PubMed ID Title Journal Year
21807936 PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer

Badve, S, Ghosh, S, Chang, KH, Johnson, EO, Mehta, R, Shah, K, de Pablo, Y

J. Cell. Sci. 2011
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Orthologous Events
PHLDA1 binds AURKA (Bos taurus)
PHLDA1 binds AURKA (Canis familiaris)
PHLDA1 binds AURKA (Danio rerio)
PHLDA1 binds AURKA (Gallus gallus)
PHLDA1 binds AURKA (Mus musculus)
PHLDA1 binds AURKA (Rattus norvegicus)
PHLDA1 binds AURKA (Sus scrofa)
PHLDA1 binds AURKA (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-29)
Reviewed
Shah, K  (2016-02-04)
Created
Orlic-Milacic, M  (2016-01-23)
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