Reactome | USP7 [cytosol]

USP7 [cytosol]

Stable Identifier

R-HSA-8853511

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin carboxyl-terminal hydrolase 7 ecNumber3.4.19.12/ecNumber, UBP7_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
22361354	ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage Kessler, BM, Dianov, GL, Ternette, N, Parsons, JL, Khoronenkova, SV, Dianova, II	Mol. Cell	2012

External Reference Information

External Reference

UniProt:Q93009 USP7

Gene Names

USP7, HAUSP

Chain

chain:1-1102

Reference Genes

BioGPS Gene:7874 USP7

COSMIC (genes):USP7 USP7

CTD Gene:7874 USP7

dbSNP Gene:7874 USP7

ENSEMBL:ENSG00000187555 USP7

HGNC:12630 USP7

KEGG:hsa:7874 USP7

Monarch:7874 USP7

NCBI Gene:7874 USP7

OMIM:602519 USP7

UCSC:Q93009 USP7

Reference Transcript

Other Identifiers

11725060_s_at

11725061_a_at

11725062_at

11748350_a_at

11752485_a_at

16823756

201498_PM_at

201498_at

201499_PM_s_at

201499_s_at

222032_PM_s_at

222032_s_at

230761_PM_at

230761_at

2823081

2823087

2823100

2823102

3679565

3679566

3679567

3679568

3679569

3679570

3679571

3679572

3679573

3679574

3679575

3679576

3679577

3679578

3679579

3679580

3679581

3679582

3679583

3679584

3679585

3679586

3679587

3679588

3679589

3679590

3679591

3679592

3679593

3679594

3679595

3679596

3679597

3679598

3679599

3679600

3679601

3679603

3679606

3679607

3679608

3679609

3679610

3679611

3679612

3679613

3679614

3679615

3679617

3679618

3679620

3679621

3679622

3679625

3679626

3679627

37672_at

7874

7999326

84835_at

88975_at

89784_at

A_23_P49481

A_24_P245108

GE587760

GE60431

GE84353

GE86510

GO:0002039

GO:0003824

GO:0004197

GO:0004843

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006281

GO:0006283

GO:0006307

GO:0006325

GO:0006355

GO:0006508

GO:0008233

GO:0008234

GO:0016567

GO:0016579

GO:0016604

GO:0016605

GO:0016787

GO:0031647

GO:0032088

GO:0032435

GO:0032991

GO:0035520

GO:0042752

GO:0043226

GO:0044027

GO:0045721

GO:0048511

GO:0050821

GO:0051090

GO:0070203

GO:0075342

GO:0101005

GO:0140096

GO:1901796

GO:1904262

GO:1904353

GO:1905279

GO:1990380

HMNXSV003020883

Hs.113759.0.A1_3p_at

Hs.129663.0.A1_3p_at

Hs.78683.0.S2_3p_at

ILMN_1729319

PH_hs_0024406

PH_hs_0038530

TC16000852.hg

Z72499_at

g4507856_3p_a_at

Participates

as a member of

UCHL3,USP7,USP9X [cytosol] (Homo sapiens)

Other forms of this molecule

USP7 [nucleoplasm]

Inferred To

UBP15 [cytosol] (Saccharomyces cerevisiae)

Usp7 [cytosol] (Drosophila melanogaster)

Usp7 [cytosol] (Mus musculus)

Usp7 [cytosol] (Rattus norvegicus)

math-33 [cytosol] (Caenorhabditis elegans)

ubp5 [cytosol] (Schizosaccharomyces pombe)

usp7 [cytosol] (Dictyostelium discoideum)

USP7 [cytosol] (Bos taurus)

USP7 [cytosol] (Canis familiaris)

USP7 [cytosol] (Gallus gallus)

USP7 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_003461.2, NP_001273386.1, NP_001308787.1

OpenTargets

ENSG00000187555

ENSEMBL

ENSP00000343535, ENSP00000371310, ENST00000381886, ENST00000344836

ZINC - Substances

UBP7_HUMAN

ZINC target

Q93009

PRO

Q93009

GlyGen

Q93009

PDB

5N9R, 4YSI, 2FOJ, 6VN5, 5KYB, 6VN3, 5WHC, 6VN6, 4M5W, 5UQV, 4M5X, 2F1Z, 2F1X, 5J7T, 5KYD, 1NBF, 5C6D, 4Z96, 7XHH, 5VSB, 2KVR, 5FWI, 7XPY, 5JTV, 5VSK, 2XXN, 5VS6, 4JJQ, 2FOP, 2YLM, 4YOC, 1NB8, 5N9T, 6F5H, 8D4Z, 6VN4, 6P5L, 6VN2, 4PYZ, 7VIJ, 3MQR, 5UQX, 3MQS, 2F1Y, 2F1W, 1YZE, 7CM2, 5KYC, 5JTJ, 1YY6, 5KYE, 6M1K, 5KYF, 4WPH, 5NGE, 5GG4, 4Z97, 5NGF, 7XHK, 5C56, 4WPI, 2FOO, 4KG9

IntEnz

3.4.19.12

HPA

ENSG00000187555-USP7

Pharos - Targets

Q93009

Orphanet

USP7

ZINC - Predictions - Purchasable

UBP7_HUMAN

HMDB Protein

HMDBP10124

Interactors (62)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.969	23
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.965	34
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.844	16
UniProt:P03211 EBNA1			0.811	7
UniProt:P08393 ICP0			0.734	4
IntAct:EBI-4399559 UBIQ			0.73	3
UniProt:Q9UQR0 SCML2			0.725	4
UniProt:O15151 MDM4	5	MDM4 [nucleoplasm] (R-HSA-349430) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502)	0.711	15
UniProt:F5H9D8 F5H9D8			0.702	13
UniProt:Q99496 RNF2	1	RNF2 [nucleoplasm] (R-HSA-389119)	0.688	5
UniProt:Q6W2J9 BCOR			0.659	4
UniProt:Q06587 RING1	1	RING1 [nucleoplasm] (R-HSA-389113)	0.656	5
UniProt:P35226 BMI1	3	BMI1 [nucleoplasm] (R-HSA-389121) p-S-BMI1 [nucleoplasm] (R-HSA-3229116) monoSUMO1-K88-BMI1 [nucleoplasm] (R-HSA-4551729)	0.646	7
UniProt:Q9BSM1 PCGF1			0.643	3
UniProt:O15355 PPM1G			0.643	3
UniProt:Q8IX18 DHX40			0.643	4
UniProt:P51784 USP11	1	USP11 [cytosol] (R-HSA-391303)	0.643	3
UniProt:P26358 DNMT1	2	DNMT1 [nucleoplasm] (R-HSA-212181) monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353)	0.643	3
UniProt:Q15170 TCAL1			0.643	4
UniProt:O35618	5	Mdm4 [nucleoplasm] (R-MMU-6782502) phospho-Mdm4 [nucleoplasm] (R-MMU-6804938) phospho-Mdm4 [nucleoplasm] (R-MMU-349441) phospho-Mdm4 [nucleoplasm] (R-MMU-349461) Mdm4 [nucleoplasm] (R-MMU-349430)	0.641	4
UniProt:Q9HC52 CBX8	1	CBX8 [nucleoplasm] (R-HSA-389117)	0.623	7
UniProt:Q8WUA2 PPIL4	1	PPIL4 [nucleoplasm] (R-HSA-8952113)	0.615	3
UniProt:P60484-1 PTEN			0.602	5
UniProt:Q9HCI5 MAGE1			0.592	2
UniProt:Q86VY4 TSYL5			0.591	4
UniProt:P35227 PCGF2	1	PCGF2 [nucleoplasm] (R-HSA-389115)	0.591	5
UniProt:O96017 CHEK2	3	p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784) CHEK2 [nucleoplasm] (R-HSA-113824) p-T68-CHEK2 [nucleoplasm] (R-HSA-113825)	0.59	2
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.573	2
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.571	8
UniProt:O15479 MAGB2			0.564	2
UniProt:Q49AR9 Q49AR9			0.556	3
UniProt:P36508 ZNF76			0.556	3
UniProt:P42166 TMPO			0.547	2
UniProt:Q53GL0 PKHO1			0.547	2
UniProt:Q96AP0 ACD	1	ACD [nucleoplasm] (R-HSA-174889)	0.547	2
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.547	2
UniProt:Q86SQ0 PHLB2			0.547	2
UniProt:Q99836 MYD88	8	MyD88 R196C [cytosol] (R-HSA-5602329) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 E65del [cytosol] (R-HSA-5602598) MYD88 [endosome membrane] (R-HSA-975123) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059)	0.543	3
UniProt:P21145 MAL			0.543	3
UniProt:Q8NG27 PJA1	1	PJA1 [cytosol] (R-HSA-975989)	0.527	2
UniProt:Q7Z6Z7 HUWE1	4	HUWE1 [ficolin-1-rich granule lumen] (R-HSA-6801467) HUWE1 [extracellular region] (R-HSA-6806466) HUWE1 [secretory granule lumen] (R-HSA-6801481) HUWE1 [cytosol] (R-HSA-975983)	0.527	2
UniProt:P30793 GCH1	1	GCH1 [cytosol] (R-HSA-1474127)	0.527	2
UniProt:A0JP26 POTB3			0.527	2
UniProt:Q8IY57 YAF2	1	YAF2 [nucleoplasm] (R-HSA-8937973)	0.527	3
UniProt:Q9BQ70 TCF25			0.527	2
UniProt:Q8WW01 TSEN15	1	TSEN15 [nucleoplasm] (R-HSA-5696772)	0.527	2
UniProt:P33991 MCM4	1	MCM4 [nucleoplasm] (R-HSA-68549)	0.527	2
UniProt:Q9BWX1 PHF7			0.527	2
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.527	3
UniProt:Q6PIJ6 FBX38			0.527	2
UniProt:B2RU33 POTEC			0.527	3
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.527	2
UniProt:O75386 TULP3	1	TULP3 [cilium] (R-HSA-5610445)	0.527	2
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.527	2
UniProt:P49915 GMPS	1	GMPS [cytosol] (R-HSA-56085)	0.527	2
UniProt:Q96EI5 TCAL4			0.527	3
UniProt:P19447 ERCC3	1	ERCC3 [nucleoplasm] (R-HSA-67439)	0.527	2
UniProt:Q5U5Q3 MEX3C	1	MEX3C [cytosol] (R-HSA-8851640)	0.524	3
UniProt:Q99426 TBCB	1	TBCB [cytosol] (R-HSA-379546)	0.508	2
UniProt:Q77UV9 Q77UV9			0.499	2
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.462	3
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.462	2

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