UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin

Stable Identifier
R-HSA-8853514
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The UBA52 precursor protein contains the ribosomal protein L40 and ubiquitin (UBA52 residues 1 to 76) which are released by proteolysis. Any of the proteases UCHL3, USP7, or USP9X can catalyze the proteolysis reaction (Larsen et al. 1998, Grou et al. 2015).

Literature References
PubMed ID Title Journal Year
26235645 The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors

Grou, CP, Pinto, MP, Mendes, AV, Domingues, P, Azevedo, JE

Sci Rep 2015
9521656 Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases

Larsen, CN, Krantz, BA, Wilkinson, KD

Biochemistry 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitin-specific protease activity of UCHL3,USP7,USP9X [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created