OTULIN,USP5 cleaves UBC yielding ubiquitin

Stable Identifier
R-HSA-8853515
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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OTULIN,USP5 cleaves UBC yielding ubiquitin
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The UBC poly-protein contains 9 Ubiquitin monomers that are released by proteolysis. Either USP5 (Falquet et al. 1995) or OTULIN can perform the proteolyic cleavage reactions (Grou et al. 2015).

Literature References
PubMed ID Title Journal Year
7851534 A human de-ubiquitinating enzyme with both isopeptidase and peptidase activities in vitro

Falquet, L, Paquet, N, Frutiger, S, Hughes, GJ, Hoang-Van, K, Jaton, JC

FEBS Lett. 1995
26235645 The de novo synthesis of ubiquitin: identification of deubiquitinases acting on ubiquitin precursors

Grou, CP, Pinto, MP, Mendes, AV, Domingues, P, Azevedo, JE

Sci Rep 2015
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitin-specific protease activity of OTULIN,USP5 [cytosol]
Physical Entity
OTULIN,USP5 [cytosol]
Activity
thiol-dependent ubiquitin-specific protease activity (0004843)
Orthologous Events
OTULIN,USP5 cleaves UBC yielding ubiquitin (Caenorhabditis elegans)
OTULIN,USP5 cleaves UBC yielding ubiquitin (Canis familiaris)
OTULIN,USP5 cleaves UBC yielding ubiquitin (Danio rerio)
OTULIN,USP5 cleaves UBC yielding ubiquitin (Dictyostelium discoideum)
OTULIN,USP5 cleaves UBC yielding ubiquitin (Drosophila melanogaster)
OTULIN,USP5 cleaves UBC yielding ubiquitin (Gallus gallus)
OTULIN,USP5 cleaves UBC yielding ubiquitin (Mus musculus)
OTULIN,USP5 cleaves UBC yielding ubiquitin (Rattus norvegicus)
OTULIN,USP5 cleaves UBC yielding ubiquitin (Xenopus tropicalis)
Authored
May, B  (2016-01-15)
Reviewed
Azevedo, JE  (2016-08-11)
Created
May, B  (2016-01-25)
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