2x p-5Y-RET:GDNF:GFRA complexes bind SHC1

Stable Identifier
R-HSA-8853737
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

GDNF stimulation of neuronal cells induces the assembly of a large protein complex containing RET, GRB2 and tyrosine-phosphorylated SHC1, p85 subunit of (PI3K), GAB2 (GAB1 in Hayashi et al. 2000) and Tyrosine-protein phosphatase non-receptor type 11 (PTPN11, SHP-2) (Besset et al. 2000). RET binds SHC1 via phosphorylated tyrosine-1062 (Asai et al. 1996, Arighi et al. 1997).

Literature References
PubMed ID Title Journal Year
9299438 Characterization of Ret-Shc-Grb2 complex induced by GDNF, MEN 2A, and MEN 2B mutations

Ohiwa, M, Murakami, H, Iwashita, T, Asai, N, Iwata, Y, Imai, T, Funahashi, H, Takagi, H, Takahashi, M

Biochem. Biophys. Res. Commun. 1997
8663426 A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins

Asai, N, Murakami, H, Iwashita, T, Takahashi, M

J. Biol. Chem. 1996
9047384 Identification of Shc docking site on Ret tyrosine kinase

Arighi, E, Alberti, L, Torriti, F, Ghizzoni, S, Rizzetti, MG, Pelicci, G, Pasini, B, Bongarzone, I, Piutti, C, Pierotti, MA, Borrello, MG

Oncogene 1997
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