Reactome | 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1

2x p-5Y-RET:GDNF:GFRA complexes bind SHC1

Stable Identifier

R-HSA-8853737

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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2x p-5Y-RET:GDNF:GFRA complexes bind SHC1

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GDNF stimulation of neuronal cells induces the assembly of a large protein complex containing RET, GRB2 and tyrosine-phosphorylated SHC1, p85 subunit of (PI3K), GAB2 (GAB1 in Hayashi et al. 2000) and Tyrosine-protein phosphatase non-receptor type 11 (PTPN11, SHP-2) (Besset et al. 2000). RET binds SHC1 via phosphorylated tyrosine-1062 (Asai et al. 1996, Arighi et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
8663426	A mutation at tyrosine 1062 in MEN2A-Ret and MEN2B-Ret impairs their transforming activity and association with shc adaptor proteins Asai, N, Murakami, H, Iwashita, T, Takahashi, M	J. Biol. Chem.	1996
9299438	Characterization of Ret-Shc-Grb2 complex induced by GDNF, MEN 2A, and MEN 2B mutations Ohiwa, M, Murakami, H, Iwashita, T, Asai, N, Iwata, Y, Imai, T, Funahashi, H, Takagi, H, Takahashi, M	Biochem. Biophys. Res. Commun.	1997
9047384	Identification of Shc docking site on Ret tyrosine kinase Arighi, E, Alberti, L, Torriti, F, Ghizzoni, S, Rizzetti, MG, Pelicci, G, Pasini, B, Bongarzone, I, Piutti, C, Pierotti, MA, Borrello, MG	Oncogene	1997