2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1

Stable Identifier
R-HSA-8853755
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane, extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylated RET binds Phospholipase C gamma 1 (PLCG1) via tyrosine 905 (Borello et al. 1996) and/or tyrosine-1015 (Lundgren et al. 2012).

Literature References
PubMed ID Title Journal Year
8628282 The full oncogenic activity of Ret/ptc2 depends on tyrosine 539, a docking site for phospholipase Cgamma

Borrello, MG, Alberti, L, Arighi, E, Bongarzone, I, Battistini, C, Bardelli, A, Pasini, B, Piutti, C, Rizzetti, MG, Mondellini, P, Radice, MT, Pierotti, MA

Mol. Cell. Biol. 1996
Participants
Input
Output
Participates
as an event of
Orthologous Events
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Bos taurus)
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Canis familiaris)
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Danio rerio)
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Gallus gallus)
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Rattus norvegicus)
2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Sus scrofa)
Authored
Jupe, S  (2016-01-25)
Reviewed
Morales, D  (2016-05-06)
Luo, W  (2016-05-17)
Created
Jupe, S  (2016-01-25)
Cite Us!