Reactome | p-5Y-RET complexes bind GRB2

p-5Y-RET complexes bind GRB2

Stable Identifier

R-HSA-8853793

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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GDNF stimulation of neuronal cells induces the assembly of a large protein complex containing RET, GRB2 and tyrosine-phosphorylated SHC1, p85 subunit of (PI3K), GAB2 (GAB1 in Hayashi et al. 2000), and Tyrosine-protein phosphatase non-receptor type 11 (PTPN11, SHP-2) (Besset et al. 2000). GAB1 was found in complexes with GRB2 only after GDNF treatment (Hayashi et al. 2000). This contrasts with reports in other systems where GAB2-GRB2 were reported to constitutively associate (Gu et al. 1998). The likely order of recruitment to RET is SHC1, GRB2, GAB1/2, similar to the signaling mechanism of the Interleukin-3 receptor (Gu et al. 2000) and many others (Adams et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
11002419	Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor Hayashi, H, Ichihara, M, Iwashita, T, Murakami, H, Shimono, Y, Kawai, K, Kurokawa, K, Murakumo, Y, Imai, T, Funahashi, H, Nakao, A, Takahashi, M	Oncogene	2000
10995764	Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase Besset, V, Scott, RP, Ibáñez, CF	J. Biol. Chem.	2000