p-5Y-RET complexes bind GRB2

Stable Identifier
R-HSA-8853793
Type
Reaction [omitted]
Species
Homo sapiens
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GDNF stimulation of neuronal cells induces the assembly of a large protein complex containing RET, GRB2 and tyrosine-phosphorylated SHC1, p85 subunit of (PI3K), GAB2 (GAB1 in Hayashi et al. 2000), and Tyrosine-protein phosphatase non-receptor type 11 (PTPN11, SHP-2) (Besset et al. 2000). GAB1 was found in complexes with GRB2 only after GDNF treatment (Hayashi et al. 2000). This contrasts with reports in other systems where GAB2-GRB2 were reported to constitutively associate (Gu et al. 1998). The likely order of recruitment to RET is SHC1, GRB2, GAB1/2, similar to the signaling mechanism of the Interleukin-3 receptor (Gu et al. 2000) and many others (Adams et al. 2012).

Literature References
PubMed ID Title Journal Year
10995764 Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase

Besset, V, Scott, RP, Ibáñez, CF

J. Biol. Chem. 2000
11002419 Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor

Hayashi, H, Ichihara, M, Iwashita, T, Murakami, H, Shimono, Y, Kawai, K, Kurokawa, K, Murakumo, Y, Imai, T, Funahashi, H, Nakao, A, Takahashi, M

Oncogene 2000
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