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What is Reactome ?
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Table of Contents
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RET [plasma membrane]
Stable Identifier
R-HSA-8853797
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Proto-oncogene tyrosine-protein kinase receptor Ret ecNumber2.7.10.1/ecNumber, RET_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
RET signaling (Homo sapiens)
ARTN binds RET:GFRA1,GFRA3 (Homo sapiens)
RET:GFRA1,GFRA3 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA3:ARTN [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA3 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
GDNF,NRTN bind RET:GFRA1,GFRA2 (Homo sapiens)
RET:GFRA1,GFRA2 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA2 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
PKA phosphorylates RET:GDNF:GFRA dimer (Homo sapiens)
2x RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA2 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA3:ARTN [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA3 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET:GFRA4:PSPN [plasma membrane] (Homo sapiens)
RET:GFRA4 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
2x p-S696-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-S696-RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
p-S696-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
p-S696-RET:GFRA1,GFRA2 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
p-S696-RET:GFRA1,GFRA3:ARTN [plasma membrane] (Homo sapiens)
p-S696-RET:GFRA1,GFRA3 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
p-S696-RET:GFRA4:PSPN [plasma membrane] (Homo sapiens)
p-S696-RET:GFRA4 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
PSPN binds RET:GFRA4 (Homo sapiens)
RET:GFRA4 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET:GFRA4:PSPN [plasma membrane] (Homo sapiens)
RET:GFRA4 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET binds GFRA1,GFRA2 (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA2 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET binds GFRA1,GFRA3 (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA3 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET binds GFRA4 (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET:GFRA4 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET dimerizes (Homo sapiens)
2x RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA2 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA3:ARTN [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA3 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET:GFRA4:PSPN [plasma membrane] (Homo sapiens)
RET:GFRA4 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA2 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA3:ARTN [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA3 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET:GFRA4:PSPN [plasma membrane] (Homo sapiens)
RET:GFRA4 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET tyrosine phosphorylation (Homo sapiens)
2x RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
RET:GFRA:GDNF complexes [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA2 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA3:ARTN [plasma membrane] (Homo sapiens)
RET:GFRA1,GFRA3 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET:GFRA4:PSPN [plasma membrane] (Homo sapiens)
RET:GFRA4 [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
RET [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07949 RET
Gene Names
RET, CDHF12, CDHR16, PTC, RET51
Chain
signal peptide:1-28, chain:29-1114, chain:29-707, chain:708-1017
Reference Genes
BioGPS Gene:5979 RET
COSMIC (genes):RET RET
CTD Gene:5979 RET
dbSNP Gene:5979 RET
ENSEMBL:ENSG00000165731 RET
HGNC:9967 RET
KEGG Gene (Homo sapiens):5979 RET
Monarch:5979 RET
NCBI Gene:5979 RET
OMIM:164761 RET
UCSC:P07949 RET
Reference Transcript
RefSeq:NM_020630.4 RET
RefSeq:NM_020975.4 RET
Other Identifiers
0003610504
0006130053
11729917_at
11733418_at
11733419_a_at
160028_s_at
16704154
1745_at
1822_at
1823_g_at
1889_s_at
205879_x_at
211421_s_at
215771_x_at
3243848
3243849
3243854
3243855
3243859
3243860
3243861
3243862
3243864
3243865
3243866
3243867
3243868
3243869
3243870
3243871
3243873
3243874
3243875
3243876
3243877
3243878
3243879
3243880
3243881
3243882
3243883
3243884
3243885
3243886
3243887
3243888
3243889
3243890
3243891
3243892
3243893
3243894
3243895
3243897
3243899
3243900
3243901
3243903
5979
7927120
91896_at
A_23_P202245
GE82572
GO:0000165
GO:0000166
GO:0000187
GO:0000902
GO:0001657
GO:0001755
GO:0001838
GO:0002376
GO:0003674
GO:0004672
GO:0004713
GO:0004714
GO:0005509
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005737
GO:0005768
GO:0005769
GO:0005886
GO:0005887
GO:0006464
GO:0006468
GO:0006950
GO:0007155
GO:0007156
GO:0007158
GO:0007165
GO:0007169
GO:0007275
GO:0007399
GO:0007411
GO:0007497
GO:0008150
GO:0008219
GO:0009058
GO:0009790
GO:0010008
GO:0010628
GO:0010976
GO:0014042
GO:0016020
GO:0016021
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0021700
GO:0030154
GO:0030155
GO:0030182
GO:0030335
GO:0030424
GO:0030425
GO:0031410
GO:0032991
GO:0033141
GO:0033619
GO:0033630
GO:0033674
GO:0034641
GO:0035799
GO:0035860
GO:0038023
GO:0040011
GO:0042493
GO:0042551
GO:0043025
GO:0043167
GO:0043226
GO:0043235
GO:0043410
GO:0045121
GO:0045793
GO:0045893
GO:0048265
GO:0048484
GO:0048646
GO:0048856
GO:0048870
GO:0050770
GO:0051897
GO:0060041
GO:0060384
GO:0061146
GO:0071300
GO:0072300
GO:0097021
GO:0098797
GO:2001241
Hs.241572.1.S1_3p_s_at
ILMN_1655610
ILMN_1666314
ILMN_1706301
M57464_s_at
PH_hs_0032778
TC10000268.hg
TC10002029.hg
g13279040_3p_a_at
g13279040_3p_s_at
g190699_3p_a_at
Participant Of
hasComponent
p-S696-RET:GFRA1,GFRA2 [plasma membrane]
p-S696-RET:GFRA1,GFRA3 [plasma membrane]
p-S696-RET:GFRA4 [plasma membrane]
RET:GFRA1,GFRA2 [plasma membrane]
RET:GFRA1,GFRA3 [plasma membrane]
RET:GFRA4 [plasma membrane]
input
RET binds GFRA1,GFRA2
RET binds GFRA1,GFRA3
RET binds GFRA4
Other forms of this molecule
p-5Y-RET [plasma membrane]
Inferred To
ret [plasma membrane] (Danio rerio)
Ret [plasma membrane] (Drosophila melanogaster)
Ret [plasma membrane] (Mus musculus)
Ret [plasma membrane] (Rattus norvegicus)
RET [plasma membrane] (Bos taurus)
RET [plasma membrane] (Canis familiaris)
RET [plasma membrane] (Gallus gallus)
RET [plasma membrane] (Sus scrofa)
fbxw4 [plasma membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_065681.1
,
NP_066124.1
ZINC - World Drugs
RET_HUMAN
OpenTargets
ENSG00000165731
ZINC - FDA approved
RET_HUMAN
ZINC - Substances
RET_HUMAN
ZINC - Biogenic
RET_HUMAN
ZINC target
P07949
PRO
P07949
PDB
2IVS
,
5FM3
,
5FM2
,
6Q2J
,
2IVT
,
4UX8
,
6I83
,
6I82
,
2IVU
,
6Q2O
,
6FEK
,
6VHG
,
4CKI
,
5AMN
,
2X2K
,
6Q2N
,
2X2L
,
6NE7
,
6Q2S
,
2X2U
,
6Q2R
,
4CKJ
,
2X2M
,
2IVV
,
1XPD
,
6NJA
,
6GL7
,
6NEC
ZINC - Investigational
RET_HUMAN
HPA
ENSG00000165731-RET
GeneCards
P07949
Ensembl
ENSP00000344798
,
ENST00000355710
,
ENSG00000165731
,
ENST00000340058
,
ENSP00000347942
Orphanet
15200
ZINC - Predictions - Purchasable
RET_HUMAN
HMDB Protein
HMDBP01526
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22681 CBL
39
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL del366-409 [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
CBL G375fs*16 [cytosol]
(R-HSA-9706211)
CBL R420* [cytosol]
(R-HSA-9706208)
CBL H398D [cytosol]
(R-HSA-9706631)
CBL Y371C [cytosol]
(R-HSA-9706694)
CBL G375S [cytosol]
(R-HSA-9706214)
CBL Y371D [cytosol]
(R-HSA-9706687)
CBL Y371S [cytosol]
(R-HSA-9706674)
CBL P417S [cytosol]
(R-HSA-9706642)
CBL H398N [cytosol]
(R-HSA-9706641)
CBL R420P [cytosol]
(R-HSA-9706193)
CBL Y371N [cytosol]
(R-HSA-9706679)
CBL R499Q [cytosol]
(R-HSA-9706677)
CBL R420L [cytosol]
(R-HSA-9706197)
CBL P417H [cytosol]
(R-HSA-9706644)
p-Y371-CBL [plasma membrane]
(R-HSA-182923)
p-Y-CBL [cytosol]
(R-HSA-8875457)
p-Y371-CBL [cytosol]
(R-HSA-182940)
PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-8848826)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
CBL [cytosol]
(R-HSA-112199)
0.697
8
UniProt:Q62985
2
Sh2b1 [cytosol]
(R-RNO-1675482)
Sh2b1 [cytosol]
(R-RNO-997253)
0.621
3
UniProt:P19174 PLCG1
6
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
0.564
2
UniProt:P40763 STAT3
10
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.564
3
UniProt:Q7Z3S9 NT2NA
0.556
3
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.553
2
UniProt:Q62077 Plcg1
10
Plcg1 [cytosol]
(R-MMU-9638030)
p-Y-Plcg1 [cytosol]
(R-MMU-9029083)
p-4Y-Plcg1 [plasma membrane]
(R-MMU-9030452)
P-Plcg1 [cytosol]
(R-MMU-1251936)
Plcg1 [plasma membrane]
(R-MMU-1251925)
phospho-Plcg1 [plasma membrane]
(R-MMU-1169084)
Plcg1 [plasma membrane]
(R-MMU-167682)
Plcg1 [cytosol]
(R-MMU-202320)
phospho-Plcg1 [cytosol]
(R-MMU-202357)
phospho-Plcg1 [plasma membrane]
(R-MMU-167679)
0.482
2
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