Reactome | RET [plasma membrane]

RET [plasma membrane]

Stable Identifier

R-HSA-8853797

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Proto-oncogene tyrosine-protein kinase receptor Ret ecNumber2.7.10.1/ecNumber, RET_HUMAN

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External Reference Information

External Reference

UniProt:P07949 RET

Gene Names

RET, CDHF12, CDHR16, PTC, RET51

Chain

signal peptide:1-28, chain:29-1114, chain:29-707, chain:708-1017

Reference Genes

BioGPS Gene:5979 RET

COSMIC (genes):RET RET

CTD Gene:5979 RET

dbSNP Gene:5979 RET

ENSEMBL:ENSG00000165731 RET

HGNC:9967 RET

KEGG Gene (Homo sapiens):5979 RET

Monarch:5979 RET

NCBI Gene:5979 RET

OMIM:164761 RET

UCSC:P07949 RET

Reference Transcript

Other Identifiers

0003610504

0006130053

11729917_at

11733418_at

11733419_a_at

160028_s_at

16704154

1745_at

1822_at

1823_g_at

18342

1889_s_at

1XPD

205879_x_at

211421_s_at

215771_x_at

2581

2IVS

2IVT

2IVU

2IVV

2X2K

2X2L

2X2M

2X2U

3243848

3243849

3243854

3243855

3243859

3243860

3243861

3243862

3243864

3243865

3243866

3243867

3243868

3243869

3243870

3243871

3243873

3243874

3243875

3243876

3243877

3243878

3243879

3243880

3243881

3243882

3243883

3243884

3243885

3243886

3243887

3243888

3243889

3243890

3243891

3243892

3243893

3243894

3243895

3243897

3243899

3243900

3243901

3243903

4CKI

4CKJ

4UX8

5979

5AMN

5FM2

5FM3

6FEK

7927120

8356

8495

91896_at

A0A024R7T2

A_23_P202245

AAA36524

AAA36786

AAH04257

AC010864

AJ297349

AK291807

BAF84496

BC004257

C9JYL6

CAA31408

CAA33333

CAA33787

CAB002581

CAB018342

CAC14882

CCDS53525

CCDS7200

CH471160

EAW86580

EAW86582

ENSG00000165731

ENSP00000344798

ENSP00000347942

ENST00000340058

ENST00000340058.5

ENST00000355710

ENST00000355710.7

EntrezGene:5979

EntrezGene:RET

g13279040_3p_a_at

g13279040_3p_s_at

g190699_3p_a_at

GE82572

GO:0000165

GO:0000166

GO:0000187

GO:0000902

GO:0001657

GO:0001755

GO:0001838

GO:0002376

GO:0003674

GO:0004672

GO:0004713

GO:0004714

GO:0005509

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005886

GO:0005887

GO:0006464

GO:0006468

GO:0006950

GO:0007155

GO:0007156

GO:0007158

GO:0007165

GO:0007169

GO:0007275

GO:0007399

GO:0007411

GO:0007497

GO:0008150

GO:0008219

GO:0009058

GO:0009790

GO:0010008

GO:0010628

GO:0010976

GO:0014042

GO:0016020

GO:0016021

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0021700

GO:0030154

GO:0030155

GO:0030182

GO:0030335

GO:0030424

GO:0030425

GO:0031410

GO:0032991

GO:0033141

GO:0033619

GO:0033630

GO:0033674

GO:0034641

GO:0035799

GO:0035860

GO:0038023

GO:0040011

GO:0042493

GO:0042551

GO:0043025

GO:0043167

GO:0043226

GO:0043231

GO:0043235

GO:0043410

GO:0045121

GO:0045793

GO:0045893

GO:0048265

GO:0048484

GO:0048646

GO:0048856

GO:0048870

GO:0050770

GO:0051897

GO:0060041

GO:0060384

GO:0061146

GO:0071300

GO:0072300

GO:0097021

GO:0098797

GO:2001241

HGNC:9967

HPA008356

HPA008495

Hs.241572.1.S1_3p_s_at

ILMN_1655610

ILMN_1666314

ILMN_1706301

IPR000719

IPR001245

IPR002126

IPR008266

IPR011009

IPR015919

IPR016249

IPR017441

IPR020635

IPR040667

IPR041163

IPR041317

LRG_518

M16029

M31213

M57464_s_at

MIM:142623

MIM:155240

MIM:162300

MIM:164761

MIM:171300

MIM:171400

MIM:209880

NM_001355216

NM_020630

NM_020975

NP_001342145

NP_065681

NP_066124

PF00028

PF07714

PF17756

PF17812

PF17813

PH_hs_0032778

PR00109

Q9BTX6

RET

RET-201

RET-202

SM00219

TC10000268.hg

TC10002029.hg

UPI00001336E1

UPI0000160664

X12949

X15262

X15786

Participant Of

hasComponent

input

Other forms of this molecule

p-5Y-RET [plasma membrane]

Inferred To

ret [plasma membrane] (Danio rerio)

ret [plasma membrane] (Xenopus tropicalis)

Ret [plasma membrane] (Drosophila melanogaster)

Ret [plasma membrane] (Mus musculus)

Ret [plasma membrane] (Rattus norvegicus)

RET [plasma membrane] (Bos taurus)

RET [plasma membrane] (Canis familiaris)

RET [plasma membrane] (Gallus gallus)

RET [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_065681.1, NP_066124.1

ZINC - World Drugs

RET_HUMAN

OpenTargets

ENSG00000165731

ZINC - FDA approved

RET_HUMAN

ZINC - Substances

RET_HUMAN

ZINC target

P07949

ZINC - Biogenic

RET_HUMAN

PRO

P07949

PDB

2IVU, 5FM3, 1XPD, 6NEC, 6FEK, 2IVT, 4UX8, 6Q2J, 2X2M, 2IVS, 6NE7, 6Q2R, 6GL7, 6Q2S, 4CKI, 6NJA, 5FM2, 2X2L, 5AMN, 2IVV, 6Q2N, 2X2U, 4CKJ, 6Q2O, 2X2K

ZINC - Investigational

RET_HUMAN

HPA

ENSG00000165731-RET

GeneCards

P07949

Ensembl

ENSP00000344798, ENST00000340058, ENST00000355710, ENSP00000347942, ENSG00000165731

Orphanet

15200

ZINC - Predictions - Purchasable

RET_HUMAN

HMDB Protein

HMDBP01526

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22681 CBL	6	p-Y371-CBL [cytosol] (R-HSA-182940) p-Y-CBL [cytosol] (R-HSA-8875457) p-Y371-CBL [plasma membrane] (R-HSA-182923) PolyUb,p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-8848826) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656) CBL [cytosol] (R-HSA-112199)	0.697	8
UniProt:Q62985	2	Sh2b1 [cytosol] (R-RNO-1675482) Sh2b1 [cytosol] (R-RNO-997253)	0.621	3
UniProt:P19174 PLCG1	6	p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.564	2
UniProt:P40763 STAT3	10	p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811) p-STAT3 [cytosol] (R-HSA-8982823) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)	0.564	3
UniProt:Q7Z3S9 NT2NA			0.556	3
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2
UniProt:Q62077 Plcg1	10	Plcg1 [cytosol] (R-MMU-9638030) p-Y-Plcg1 [cytosol] (R-MMU-9029083) p-4Y-Plcg1 [plasma membrane] (R-MMU-9030452) P-Plcg1 [cytosol] (R-MMU-1251936) Plcg1 [plasma membrane] (R-MMU-1251925) phospho-Plcg1 [plasma membrane] (R-MMU-1169084) Plcg1 [plasma membrane] (R-MMU-167682) Plcg1 [cytosol] (R-MMU-202320) phospho-Plcg1 [cytosol] (R-MMU-202357) phospho-Plcg1 [plasma membrane] (R-MMU-167679)	0.482	2