VENTX stimulates p16-INK4A transcription

Stable Identifier
R-HSA-8853921
Type
Reaction [omitted]
Species
Homo sapiens
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Binding of VENTX to the p16-INK4A-specific CDKN2A promoter stimulates p16-INK4A expression. p16-INK4A acts as an inhibitor of cyclin-dependent kinases CDK4 and CDK6 and prevents CDK4/6-mediated inactivation of the RB1 tumor suppressor. Up-regulation of p16-INK4A contributes to VENTX-mediated cell cycle arrest (Wu et al. 2011). VENTX-mediated cell cycle arrest is implicated as an important step in differentiation of human hematopoietic cells (Gao et al. 2012).

Literature References
PubMed ID Title Journal Year
21325273 VentX trans-activates p53 and p16ink4a to regulate cellular senescence

Wu, X, Gao, H, Ke, W, Hager, M, Xiao, S, Freeman, MR, Zhu, Z

J. Biol. Chem. 2011
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