Binding of VENTX to the p16-INK4A-specific CDKN2A promoter stimulates p16-INK4A expression. p16-INK4A acts as an inhibitor of cyclin-dependent kinases CDK4 and CDK6 and prevents CDK4/6-mediated inactivation of the RB1 tumor suppressor. Up-regulation of p16-INK4A contributes to VENTX-mediated cell cycle arrest (Wu et al. 2011). VENTX-mediated cell cycle arrest is implicated as an important step in differentiation of human hematopoietic cells (Gao et al. 2012).