VENTX disrupts binding of CTNNB1 (beta-catenin) to TCF4 or LEF1

Stable Identifier
R-HSA-8853965
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

VENTX binds to TCF4/LEF1 transcription factors at the cyclin D1 (CCND1) promoter and disrupts the interaction of beta-catenin (CTNNB1) with TCF4 and/or LEF1 (Gao et al. 2010).

Literature References
PubMed ID Title Journal Year
20028861 VentX, a novel lymphoid-enhancing factor/T-cell factor-associated transcription repressor, is a putative tumor suppressor

Gao, H, Le, Y, Wu, X, Silberstein, LE, Giese, RW, Zhu, Z

Cancer Res. 2010
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!