Proteasome degrades AURKA ubiquitinated by SCF-FBXL7

Stable Identifier
R-HSA-8854044
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Upon ubiquitination by the SCF-FBXL7 E3 ubiquitin ligase complex, aurora kinase A (AURKA) is degraded by the proteasome (Coon et al. 2012).

Literature References
PubMed ID Title Journal Year
22306998 Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest

Coon, TA, Glasser, JR, Mallampalli, RK, Chen, BB

Cell Cycle 2012
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created