SCF-FBXL18 ubiquitinates FBXL7

Stable Identifier
R-HSA-8854051
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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SCF-FBXL18 ubiquitinates FBXL7
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FBXL18, a substrate recognition subunit of the SCF E3 ubiquitin ligase complex can bind to the FQ motif of FBXL7. The E3 ubiquitin ligase complex SCF-FBXL18 (SKP1:CUL1:RBX1:FBXL18) polyubiquitinates FBXL7 on lysine residue K109, targeting it for proteasome-mediated degradation (Liu et al. 2015).

Literature References
PubMed ID Title Journal Year
25654763 F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7

Liu, Y, Lear, T, Zhao, Y, Zhao, J, Zou, C, Chen, BB, Mallampalli, RK

Cell Death Dis 2015
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (0031146)
Catalyst Activity

ubiquitin protein ligase activity of SKP1:CUL1:RBX1:FBXL18 [cytosol]

Physical Entity
SKP1:CUL1:RBX1:FBXL18 [cytosol] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
SCF-FBXL18 ubiquitinates FBXL7 (Bos taurus)
SCF-FBXL18 ubiquitinates FBXL7 (Canis familiaris)
SCF-FBXL18 ubiquitinates FBXL7 (Danio rerio)
SCF-FBXL18 ubiquitinates FBXL7 (Drosophila melanogaster)
SCF-FBXL18 ubiquitinates FBXL7 (Gallus gallus)
SCF-FBXL18 ubiquitinates FBXL7 (Mus musculus)
SCF-FBXL18 ubiquitinates FBXL7 (Rattus norvegicus)
SCF-FBXL18 ubiquitinates FBXL7 (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-01-27)
Reviewed
Grant, R  (2016-05-13)
Lindon, C  (2016-05-13)
Created
Orlic-Milacic, M  (2016-01-27)
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