SCF-FBXL18 ubiquitinates FBXL7

Stable Identifier
R-HSA-8854051
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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FBXL18, a substrate recognition subunit of the SCF E3 ubiquitin ligase complex can bind to the FQ motif of FBXL7. The E3 ubiquitin ligase complex SCF-FBXL18 (SKP1:CUL1:RBX1:FBXL18) polyubiquitinates FBXL7 on lysine residue K109, targeting it for proteasome-mediated degradation (Liu et al. 2015).

Literature References
PubMed ID Title Journal Year
25654763 F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7

Liu, Y, Lear, T, Zhao, Y, Zhao, J, Zou, C, Chen, BB, Mallampalli, RK

Cell Death Dis 2015
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of SKP1:CUL1:RBX1:FBXL18 [cytosol]
Physical Entity
Activity
Orthologous Events
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