SCF-FBXL18 ubiquitinates FBXL7

Stable Identifier
R-HSA-8854051
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SCF-FBXL18 ubiquitinates FBXL7
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

FBXL18, a substrate recognition subunit of the SCF E3 ubiquitin ligase complex can bind to the FQ motif of FBXL7. The E3 ubiquitin ligase complex SCF-FBXL18 (SKP1:CUL1:RBX1:FBXL18) polyubiquitinates FBXL7 on lysine residue K109, targeting it for proteasome-mediated degradation (Liu et al. 2015).

Literature References
PubMed ID Title Journal Year
25654763 F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7

Liu, Y, Lear, T, Zhao, Y, Zhao, J, Zou, C, Chen, BB, Mallampalli, RK

Cell Death Dis 2015
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (0031146)
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of SKP1:CUL1:RBX1:FBXL18 [cytosol]
Physical Entity
SKP1:CUL1:RBX1:FBXL18 [cytosol]
Activity
ubiquitin protein ligase activity (0061630)
Orthologous Events
SCF-FBXL18 ubiquitinates FBXL7 (Bos taurus)
SCF-FBXL18 ubiquitinates FBXL7 (Canis familiaris)
SCF-FBXL18 ubiquitinates FBXL7 (Danio rerio)
SCF-FBXL18 ubiquitinates FBXL7 (Dictyostelium discoideum)
SCF-FBXL18 ubiquitinates FBXL7 (Drosophila melanogaster)
SCF-FBXL18 ubiquitinates FBXL7 (Gallus gallus)
SCF-FBXL18 ubiquitinates FBXL7 (Mus musculus)
SCF-FBXL18 ubiquitinates FBXL7 (Rattus norvegicus)
SCF-FBXL18 ubiquitinates FBXL7 (Sus scrofa)
SCF-FBXL18 ubiquitinates FBXL7 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-27)
Reviewed
Grant, R  (2016-05-13)
Lindon, C  (2016-05-13)
Created
Orlic-Milacic, M  (2016-01-27)
Cite Us!