FBXL18, a substrate recognition subunit of the SCF E3 ubiquitin ligase complex can bind to the FQ motif of FBXL7. The E3 ubiquitin ligase complex SCF-FBXL18 (SKP1:CUL1:RBX1:FBXL18) polyubiquitinates FBXL7 on lysine residue K109, targeting it for proteasome-mediated degradation (Liu et al. 2015).
Liu, Y, Lear, T, Zhao, Y, Zhao, J, Zou, C, Chen, BB, Mallampalli, RK
ubiquitin protein ligase activity of SKP1:CUL1:RBX1:FBXL18 [cytosol]
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